Bibliographic Details
| Title: |
Faecal hsa-miR-7704 inhibits the growth and adhesion of Bifidobacterium longum by suppressing ProB and aggravates hepatic encephalopathy |
| Authors: |
Yuchong Wang, Yuyu Li, Longxian Lv, Liying Zhu, Liang Hong, Xueyao Wang, Yu Zhang, Xin Wang, Hongyan Diao |
| Source: |
npj Biofilms and Microbiomes, Vol 10, Iss 1, Pp 1-14 (2024) |
| Publisher Information: |
Nature Portfolio, 2024. |
| Publication Year: |
2024 |
| Collection: |
LCC:Microbial ecology |
| Subject Terms: |
Microbial ecology, QR100-130 |
| More Details: |
Abstract Both gut microbiome and microRNAs (miRNAs) play a role in the development of hepatic encephalopathy (HE). However, the functional link between the microbiome and host-derived miRNAs in faeces remains poorly understood. In the present study, patients with HE had an altered gut microbiome and faecal miRNAs compared with patients with chronic hepatitis B. Transferring faeces and faecal miRNAs from patients with HE to the recipient mice aggravated thioacetamide-induced HE. Oral gavage of hsa-miR-7704, a host-derived miRNA highly enriched in faeces from patients with HE, aggravated HE in mice in a microbiome-dependent manner. Mechanistically, hsa-miR-7704 inhibited the growth and adhesion of Bifidobacterium longum by suppressing proB. B. longum and its metabolite acetate alleviated HE by inhibiting microglial activation and ammonia production. Our findings reveal the role of miRNA–microbiome axis in HE and suggest that faecal hsa-miR-7704 are potential regulators of HE progression. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2055-5008 |
| Relation: |
https://doaj.org/toc/2055-5008 |
| DOI: |
10.1038/s41522-024-00487-8 |
| Access URL: |
https://doaj.org/article/21b711a24cb2414ea5ec7fefa076ff3f |
| Accession Number: |
edsdoj.21b711a24cb2414ea5ec7fefa076ff3f |
| Database: |
Directory of Open Access Journals |
