Academic Journal
Per and polyfluoroalkyl substances affect thyroid hormones for people with a history of exposure from drinking water
| Title: | Per and polyfluoroalkyl substances affect thyroid hormones for people with a history of exposure from drinking water |
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| Authors: | Taylor S. Noyes, Laura M. Abington, T. Joost van ‘t Erve, Ling Wang, Jennifer M. McDonald, Elizabeth A. Wasilevich, Jennifer S. Gray, Timothy A. Karrer, Kristine Smith, Jordan M. Bailey |
| Source: | Scientific Reports, Vol 15, Iss 1, Pp 1-12 (2025) |
| Publisher Information: | Nature Portfolio, 2025. |
| Publication Year: | 2025 |
| Collection: | LCC:Medicine LCC:Science |
| Subject Terms: | Per- and polyfluoroalkyl substances, PFAS, Epidemiology, Endocrine disruption, Thyroid hormone, Mixture analysis, Medicine, Science |
| More Details: | Abstract Per- and polyfluoroalkyl substances (PFAS) may disrupt thyroid hormones although the literature shows mixed evidence of this effect and exposure to mixtures of PFAS remains poorly understood. We used the Michigan PFAS Exposure and Health Study cohort to examine linear and nonlinear associations between serum PFAS concentrations, both alone and as a mixture, and serum thyroid hormone concentrations. Study participants included 728 adolescents and adults living in an area with past PFAS contamination of drinking water. We quantified 39 individual PFAS and four thyroid hormones in serum from participants between the years 2020 and 2021. Linear regression, weighted quantile sum (WQS) regression, supervised Principal Component Analysis (PCA), and Bayesian Kernel Machine Regression (BKMR) were used. When analyzed individually, a 1% increase in PFUnA serum concentrations was associated with a 0.023% decrease in TT3 concentration (95% CI: -0.04%, -0.01%, p |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2045-2322 |
| Relation: | https://doaj.org/toc/2045-2322 |
| DOI: | 10.1038/s41598-025-91977-y |
| Access URL: | https://doaj.org/article/e21aaf926ba04dadb22d4d2cf7a59186 |
| Accession Number: | edsdoj.21aaf926ba04dadb22d4d2cf7a59186 |
| Database: | Directory of Open Access Journals |
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| ISSN: | 20452322 |
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| DOI: | 10.1038/s41598-025-91977-y |
| Published in: | Scientific Reports |
| Language: | English |