Bibliographic Details
| Title: |
Colorectal Cancer after Kidney Transplantation: A Screening Colonoscopy Case-Control Study |
| Authors: |
Francesca Privitera, Rossella Gioco, Alba Ilari Civit, Daniela Corona, Simone Cremona, Lidia Puzzo, Salvatore Costa, Giuseppe Trama, Flavia Mauceri, Aurelio Cardella, Giuseppe Sangiorgio, Riccardo Nania, Pierfrancesco Veroux, Massimiliano Veroux |
| Source: |
Biomedicines, Vol 9, Iss 8, p 937 (2021) |
| Publisher Information: |
MDPI AG, 2021. |
| Publication Year: |
2021 |
| Collection: |
LCC:Biology (General) |
| Subject Terms: |
kidney transplantation, post-transplant cancer, colorectal cancer, colonoscopy, screening, healthy, Biology (General), QH301-705.5 |
| More Details: |
The incidence of colorectal cancer in kidney transplant recipients has been previously reported with conflicting results. In this study, we investigated if the incidence of colorectal advanced neoplasms in kidney transplant recipients, evaluated with screening colonoscopy, was higher than in healthy individuals. One-hundred sixty kidney transplant recipients undergoing screening colonoscopy were compared with 594 age- and sex-matched healthy individuals. Advanced colorectal neoplasia was found in 22 patients (13.7%), including four patients (2.5%) with colorectal cancer. Compared with the healthy population, kidney transplant recipients did not have an increased risk of developing a colorectal cancer (OR 0.69; 95% CI 0.236–2.063, p = 0.688) although it developed at a younger age. In contrast, kidney transplant recipients had a higher risk of developing an advanced adenoma compared with the control group (OR 1.65; 95% CI 0.930–2.981, p = 0.04). In conclusion, kidney transplant recipients did not have an increased incidence of colorectal cancer compared with healthy population. However, transplant patients displayed a higher incidence of colorectal adenomas, suggesting that screening colonoscopy in kidney transplant recipients should be expanded to include even younger recipients ( |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2227-9059 |
| Relation: |
https://www.mdpi.com/2227-9059/9/8/937; https://doaj.org/toc/2227-9059 |
| DOI: |
10.3390/biomedicines9080937 |
| Access URL: |
https://doaj.org/article/219dbc986052445c8bd33403d56cd240 |
| Accession Number: |
edsdoj.219dbc986052445c8bd33403d56cd240 |
| Database: |
Directory of Open Access Journals |
