Antiviral treatment using the adenosine nucleoside analogue GS‐441524 in cats with clinically diagnosed neurological feline infectious peritonitis
| Title: | Antiviral treatment using the adenosine nucleoside analogue GS‐441524 in cats with clinically diagnosed neurological feline infectious peritonitis |
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| Authors: | Peter J. Dickinson, Michael Bannasch, Sara M. Thomasy, Vishal D. Murthy, Karen M. Vernau, Molly Liepnieks, Elizabeth Montgomery, Kelly E. Knickelbein, Brian Murphy, Niels C. Pedersen |
| Source: | Journal of Veterinary Internal Medicine, Vol 34, Iss 4, Pp 1587-1593 (2020) |
| Publisher Information: | Wiley, 2020. |
| Publication Year: | 2020 |
| Collection: | LCC:Veterinary medicine |
| Subject Terms: | antiviral, cat, corona virus, ophthalmology, Veterinary medicine, SF600-1100 |
| More Details: | Abstract Feline infectious peritonitis (FIP) is caused by a mutant biotype of the feline enteric coronavirus. The resulting FIP virus (FIPV) commonly causes central nervous system (CNS) and ocular pathology in cases of noneffusive disease. Over 95% of cats with FIP will succumb to disease in days to months after diagnosis despite a variety of historically used treatments. Recently developed antiviral drugs have shown promise in treatment of nonneurological FIP, but data from neurological FIP cases are limited. Four cases of naturally occurring FIP with CNS involvement were treated with the antiviral nucleoside analogue GS‐441524 (5‐10 mg/kg) for at least 12 weeks. Cats were monitored serially with physical, neurologic, and ophthalmic examinations. One cat had serial magnetic resonance imaging (MRI), cerebrospinal fluid (CSF) analysis (including feline coronavirus [FCoV]) titers and FCoV reverse transcriptase [RT]‐PCR) and serial ocular imaging using Fourier‐domain optical coherence tomography (FD‐OCT) and in vivo confocal microscopy (IVCM). All cats had a positive response to treatment. Three cats are alive off treatment (528, 516, and 354 days after treatment initiation) with normal physical and neurologic examinations. One cat was euthanized 216 days after treatment initiation following relapses after primary and secondary treatment. In 1 case, resolution of disease was defined based on normalization of MRI and CSF findings and resolution of cranial and caudal segment disease with ocular imaging. Treatment with GS‐441524 shows clinical efficacy and may result in clearance and long‐term resolution of neurological FIP. Dosages required for CNS disease may be higher than those used for nonneurological FIP. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 1939-1676 0891-6640 04475887 |
| Relation: | https://doaj.org/toc/0891-6640; https://doaj.org/toc/1939-1676 |
| DOI: | 10.1111/jvim.15780 |
| Access URL: | https://doaj.org/article/da216336e1b044758875a91d5f2c82f1 |
| Accession Number: | edsdoj.216336e1b044758875a91d5f2c82f1 |
| Database: | Directory of Open Access Journals |
| ISSN: | 19391676 08916640 04475887 |
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| DOI: | 10.1111/jvim.15780 |
| Published in: | Journal of Veterinary Internal Medicine |
| Language: | English |