| Title: |
A-to-I miR-378a-3p editing can prevent melanoma progression via regulation of PARVA expression |
| Authors: |
Guermarie Velazquez-Torres, Einav Shoshan, Cristina Ivan, Li Huang, Enrique Fuentes-Mattei, Harrison Paret, Sun Jin Kim, Cristian Rodriguez-Aguayo, Victoria Xie, Denise Brooks, Steven J. M. Jones, A. Gordon Robertson, George Calin, Gabriel Lopez-Berenstein, Anil Sood, Menashe Bar-Eli |
| Source: |
Nature Communications, Vol 9, Iss 1, Pp 1-7 (2018) |
| Publisher Information: |
Nature Portfolio, 2018. |
| Publication Year: |
2018 |
| Collection: |
LCC:Science |
| Subject Terms: |
Science |
| More Details: |
In melanoma, reduced ADAR1 impairs A-to-I microRNA editing. Here, the authors show that miR-378a-3p undergoes this editing in non-metastatic cells and the edited form of miR-378a-3p binds to the PARVA oncogene, inhibiting its expression and preventing melanoma progression and metastasis. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2041-1723 |
| Relation: |
https://doaj.org/toc/2041-1723 |
| DOI: |
10.1038/s41467-018-02851-7 |
| Access URL: |
https://doaj.org/article/dd20c2509c0c46dbbe02e75f436eee1a |
| Accession Number: |
edsdoj.20c2509c0c46dbbe02e75f436eee1a |
| Database: |
Directory of Open Access Journals |
