Academic Journal
An injectable supramolecular antimicrobial hydrogel based on hyaluronic acid with dynamic borate bond and hydrogen bond crosslinking for sinusitis treatment
| Title: | An injectable supramolecular antimicrobial hydrogel based on hyaluronic acid with dynamic borate bond and hydrogen bond crosslinking for sinusitis treatment |
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| Authors: | Qianqian Zhao, Datao Hu, Ting Wang, Hanchao Zhou, Jinli Gao, Ke Wang, Daqing Zhao, Leping Liang |
| Source: | Carbohydrate Polymer Technologies and Applications, Vol 8, Iss , Pp 100584- (2024) |
| Publisher Information: | Elsevier, 2024. |
| Publication Year: | 2024 |
| Collection: | LCC:Biochemistry |
| Subject Terms: | Dynamic borate, Hydrogen bond, Formation mechanism, Antibacterial properties, pH/ROS response, Biochemistry, QD415-436 |
| More Details: | In this study, chlorogenic acid-modified hyaluronic acid (HA-CGA) and phenylboric acid-modified ciprofloxacin (Cip-BPA) were synthesized and their structures were analyzed by 1HNMR and 13CNMR. Following, a dynamic borate and hydrogen bond crosslinked HCCB hydrogel was prepared by mixing HA-CGA and Cip-BPA solution. Its properties and gel formation mechanism were studied by means of ratio optimization, scanning electron microscopy, rheology, 11B-NMR and temperature-changing infrared spectroscopy. The basic properties and bioactivity of HCCB hydrogel were investigated by in vitro antibacterial experiment, in vitro anti-inflammatory oxidation experiment and biocompatibility test. We found that borate ester bond and hydrogen bond are important driving forces for the formation of HCCB hydrogels, and when the molar ratio of chlorogenic acid in HA-CGA and phenylboronic acid in Cip-BPA is 2:1, the properties of HCCB hydrogels formed are the best. It has excellent antibacterial properties, anti-inflammatory and antioxidant properties, good biocompatibility and pH/ROS response. The successful preparation of the gel and its excellent properties indicate that it has great potential in the treatment of some inflammation treatment. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2666-8939 59590904 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2666893924001646; https://doaj.org/toc/2666-8939 |
| DOI: | 10.1016/j.carpta.2024.100584 |
| Access URL: | https://doaj.org/article/20b59590904147128fd1ca44f263f20d |
| Accession Number: | edsdoj.20b59590904147128fd1ca44f263f20d |
| Database: | Directory of Open Access Journals |
| ISSN: | 26668939 59590904 |
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| DOI: | 10.1016/j.carpta.2024.100584 |
| Published in: | Carbohydrate Polymer Technologies and Applications |
| Language: | English |