Bibliographic Details
| Title: |
Impact of antiretroviral treatment on height evolution of HIV infected children |
| Authors: |
Patrinee Traisathit, Saïk Urien, Sophie Le Coeur, Sakulrat Srirojana, Noppadon Akarathum, Suparat Kanjanavanit, Chaiwat Ngampiyaskul, Sawitree Krikajornkitti, Nicole Ngo-Giang-Huong, Marc Lallemant, Gonzague Jourdain |
| Source: |
BMC Pediatrics, Vol 19, Iss 1, Pp 1-9 (2019) |
| Publisher Information: |
BMC, 2019. |
| Publication Year: |
2019 |
| Collection: |
LCC:Pediatrics |
| Subject Terms: |
Asia, antiretroviral therapy, catch-up growth, height-growth velocity, HIV-infected children, Thailand, Pediatrics, RJ1-570 |
| More Details: |
Abstract Background Antiretroviral treatment (ART) has been shown to have a beneficial effect on the weight evolution but its effect on height remains unclear. We described patterns of height evolution and identified predictors of catch-up growth in HIV-infected children on ART. Methods To describe the height evolution from birth to adulthood, we developed a nonlinear mixed effect model using data from perinatally HIV-infected children who initiated ART from 1999 to 2013 in a prospective cohort study in Thailand. The main covariates of interest were: sex, ART regimen (dual nucleoside reverse-transcriptase inhibitor, non-nucleoside reverse transcriptase inhibitor (NNRTI)-, or protease inhibitor (PI)-based), baseline CD4 percentage, HIV-RNA load and CDC HIV Classification stage and occurrence of AIDS-defining events. Results A total 477 children (43% boys) contributed 18,596 height measurements over a median duration of 6.3 years on ART (interquartile range, 3.0 to 8.3). At ART initiation, median age was 6.2 years (1.8 to 9.6), 16% of children were underweight (weight-for-age z-score |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1471-2431 |
| Relation: |
http://link.springer.com/article/10.1186/s12887-019-1663-8; https://doaj.org/toc/1471-2431 |
| DOI: |
10.1186/s12887-019-1663-8 |
| Access URL: |
https://doaj.org/article/20aeb31082bb49fe96563a58a14a40fb |
| Accession Number: |
edsdoj.20aeb31082bb49fe96563a58a14a40fb |
| Database: |
Directory of Open Access Journals |
