Bibliographic Details
| Title: |
The POR rs10954732 polymorphism decreases susceptibility to hepatocellular carcinoma and hepsin as a prognostic biomarker correlated with immune infiltration based on proteomics |
| Authors: |
Yan Fang, Hongming Yang, Guiming Hu, Jiakun Lu, Jun Zhou, Na Gao, Yuhan Gu, Cunzhen Zhang, Jinhuan Qiu, Yuanyuan Guo, Yunfei Zhang, Qiang Wen, Hailing Qiao |
| Source: |
Journal of Translational Medicine, Vol 20, Iss 1, Pp 1-17 (2022) |
| Publisher Information: |
BMC, 2022. |
| Publication Year: |
2022 |
| Collection: |
LCC:Medicine |
| Subject Terms: |
Hepatocellular carcinoma, POR, Polymorphisms, HPN, Proteomics, Medicine |
| More Details: |
Abstract The effect of the cytochrome P450 oxidoreductase (POR) rs10954732 (G > A) polymorphism on hepatocellular carcinoma (HCC) susceptibility is unknown. Here we found that A allele carriers showed a 69% decrease in susceptibility to HCC with overall survival (OS) prolonged to 199%, accompanied by lower activity for cytochrome P450 2E1. A total of 222 differentially expressed proteins were mainly enriched in neutrophil and T cell activation and involved in the immune and inflammatory responses, constituting the altered immune tumor microenvironment related with A allele by proteomics analysis. Hepsin (HPN) showed significant down-regulation in HCC and up-regulation in A allele carriers. A lower HPN level was associated with increased susceptibility to HCC and a worse prognosis. Moreover, HPN is a potential independent prognostic biomarker for HCC and is strongly associated with clinicopathological features, tumor-infiltrating status of immune cells both in our discovery cohort and database surveys. Our findings provide a new potential mechanism by which HPN may play an important role in the susceptibility of rs10954732 A allele carriers to HCC and their prognosis through tumor immune infiltration, thus offering potential insights for future studies on tumor immunotherapy. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1479-5876 |
| Relation: |
https://doaj.org/toc/1479-5876 |
| DOI: |
10.1186/s12967-022-03282-1 |
| Access URL: |
https://doaj.org/article/2033194e2c7449e9a707cddc596dcd12 |
| Accession Number: |
edsdoj.2033194e2c7449e9a707cddc596dcd12 |
| Database: |
Directory of Open Access Journals |
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