Bibliographic Details
| Title: |
The profile and clinical outcomes of patients with renal involvement due to IgA vasculitis: is azathioprine a good option for treatment? |
| Authors: |
Vânia Schinzel, Jade Dib Fernandez, Gleice Clemente, Melissa Mariti Fraga, Maria Cristina Andrade, Claudio Arnaldo Len, Maria Teresa Terreri |
| Source: |
Advances in Rheumatology, Vol 59, Iss 1, Pp 1-6 (2019) |
| Publisher Information: |
BMC, 2019. |
| Publication Year: |
2019 |
| Collection: |
LCC:Diseases of the musculoskeletal system
LCC:Immunologic diseases. Allergy |
| Subject Terms: |
Henoch-Schönlein Purpura, IgA vasculitis, Nephritis, Vasculitis, Childhood, Azathioprine, Diseases of the musculoskeletal system, RC925-935, Immunologic diseases. Allergy, RC581-607 |
| More Details: |
Abstract Background The Henoch-Schönlein Purpura (HSP) orIgA vasculitis is the most common vasculitis of childhood and may occur with renal involvement, with hematuria and / or proteinuria, and may cause severe and non-reversible sequelae. Objectives To establish the profile of patients with renal involvement due to IgA vasculitisand to describe our experience with the use of azathioprine to treat patients with nephritis. Methods Clinical data were retrospectively collected from medical records of patients with IgA vasculitiswho attended the pediatric rheumatology unit between 1995 and 2017. Patients were separated into two groups based on whether or notthey weretreated with non-glucocorticoid immunosuppressants. Results From the178 patients with IgA vasculitis,nephritis was found in67 patients (37.6%), 13 of whom receivedtreatment with non-glucocorticoid immunosuppressants. Ten patients responded well to azathioprine and 1 patient to cyclosporine. Forty patients received oral glucocorticoids, whilst 16received intravenous glucocorticoids. Conclusion Azathioprine may be beneficial in the treatment of IgA vasculitis with renal involvement. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2523-3106 |
| Relation: |
http://link.springer.com/article/10.1186/s42358-019-0064-x; https://doaj.org/toc/2523-3106 |
| DOI: |
10.1186/s42358-019-0064-x |
| Access URL: |
https://doaj.org/article/d1fcf94635504ffa8ecbc06dfd7ad556 |
| Accession Number: |
edsdoj.1fcf94635504ffa8ecbc06dfd7ad556 |
| Database: |
Directory of Open Access Journals |
