Bibliographic Details
| Title: |
Ribes nigrum leaf extract downregulates pro-inflammatory gene expression and regulates redox balance in microglial cells |
| Authors: |
Alvard Minasyan, Vivien Pires, Catherine Gondcaille, Mikayel Ginovyan, Marika Mróz, Stéphane Savary, Mustapha Cherkaoui-Malki, Barbara Kusznierewicz, Agnieszka Bartoszek, Pierre Andreoletti, Naira Sahakyan |
| Source: |
BMC Complementary Medicine and Therapies, Vol 25, Iss 1, Pp 1-17 (2025) |
| Publisher Information: |
BMC, 2025. |
| Publication Year: |
2025 |
| Collection: |
LCC:Other systems of medicine |
| Subject Terms: |
Oxidative stress, Armenian flora, Reactive oxygen species, Polyphenols, Neurodegenerative disorders, Other systems of medicine, RZ201-999 |
| More Details: |
Abstract Background This study focuses on the investigation of the antioxidant and anti-inflammatory activities of alcohol extracts from Ribes nigrum leaves on murine BV-2 microglial Wt and Acyl-CoA oxidase 1 deficient (Acox1 −/− ) cell line models, useful for the investigation of some neurodegenerative disorders. Methods The extract chemical composition was analyzed via LC-Q-Orbitrap HRMS. Various assays, including DPPH, MTT, and H2DCFDA, were used to assess the extract’s antioxidant capacity, cell viability, and reactive oxygen species (ROS) production. Immunoblotting and RT-qPCR techniques were employed to measure protein expression and gene transcription in treated cells. Statistical analysis was conducted using GraphPad Prism, with significance determined at p |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2662-7671 |
| Relation: |
https://doaj.org/toc/2662-7671 |
| DOI: |
10.1186/s12906-025-04780-7 |
| Access URL: |
https://doaj.org/article/1f7854218b474227a32570fff04e1830 |
| Accession Number: |
edsdoj.1f7854218b474227a32570fff04e1830 |
| Database: |
Directory of Open Access Journals |
