Academic Journal
Adult Patients Affected by Cystic Fibrosis in Therapy with Cystic Fibrosis Transmembrane Regulator Modulators and Lung Transplant: Renal Function, Metabolic and Nutritional Status
| Title: | Adult Patients Affected by Cystic Fibrosis in Therapy with Cystic Fibrosis Transmembrane Regulator Modulators and Lung Transplant: Renal Function, Metabolic and Nutritional Status |
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| Authors: | Silvia Lai, Sandro Mazzaferro, Anna Paola Mitterhofer, Francesca Tinti, Enea Bonci, Antonello Giovannetti, Claudio Casella, Adolfo Marco Perrotta, Domenico Bagordo, Manuel Murciano, Alessandro Galani, Camilla Celani, Patrizia Troiani, Giuseppe Cimino, Paolo Palange |
| Source: | Journal of Nutrition and Metabolism, Vol 2020 (2020) |
| Publisher Information: | Hindawi Limited, 2020. |
| Publication Year: | 2020 |
| Collection: | LCC:Nutritional diseases. Deficiency diseases |
| Subject Terms: | Nutritional diseases. Deficiency diseases, RC620-627 |
| More Details: | Background. Cystic fibrosis (CF) is one of the most frequent genetic diseases. The discovery and implementation of new therapies prolonged the survival of CF patients in the last years. Evaluation of long-term complications could be useful to improve the outcome of these patients. Aim of the Study. To evaluate renal function, metabolic, nutritional, and inflammatory status in CF patients on cystic fibrosis transmembrane regulator (CFTR) modulators therapy as well as lung transplant recipients (LRs) and patients on conservative therapy (control group). Materials and Methods. We performed a prospective, longitudinal study on 69 CF patients. Clinical and laboratory parameters (metabolic and nutritional indices and inflammatory markers) were evaluated in all patients before starting CFTR therapy or transplant (T0) and after 3 years (T1). Results. We enrolled 69 CF patients (42 males). Patients were distributed into three groups. The average age was 35.01 ± 10.57 years for the control group (group 0), 32.47 ± 9.40 years for patients on CFTR modulators therapy (group 1), and 38.93 ± 7.14 years for LRs (group 2). At T1, we showed a significant difference among the three groups in terms of renal function indices: creatinine, eGFR, serum nitrogen as well as serum uric acid, sodium, and potassium (p |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2090-0724 2090-0732 |
| Relation: | https://doaj.org/toc/2090-0724; https://doaj.org/toc/2090-0732 |
| DOI: | 10.1155/2020/6183969 |
| Access URL: | https://doaj.org/article/1f63395724f844d295c27a9058c92665 |
| Accession Number: | edsdoj.1f63395724f844d295c27a9058c92665 |
| Database: | Directory of Open Access Journals |
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| ISSN: | 20900724 20900732 |
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| DOI: | 10.1155/2020/6183969 |
| Published in: | Journal of Nutrition and Metabolism |
| Language: | English |