Academic Journal
Bofutsushosan (Fangfengtongshengsan) improves early stages of NASH via the gut–liver axis in diabetes-induced NASH model mice
| Title: | Bofutsushosan (Fangfengtongshengsan) improves early stages of NASH via the gut–liver axis in diabetes-induced NASH model mice |
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| Authors: | Mitsue Nishiyama, Shiori Ishizawa, Akinori Nishi, Akinobu Taketomi, Toru Kono |
| Source: | Pharmacological Research - Modern Chinese Medicine, Vol 11, Iss , Pp 100440- (2024) |
| Publisher Information: | Elsevier, 2024. |
| Publication Year: | 2024 |
| Collection: | LCC:Other systems of medicine LCC:Therapeutics. Pharmacology |
| Subject Terms: | Non-alcoholic fatty liver disease, Diabetes mellitus, Gastrointestinal microbiome, Kampo, Bofutsushosan, Gut–liver axis, Other systems of medicine, RZ201-999, Therapeutics. Pharmacology, RM1-950 |
| More Details: | Background: The mechanisms underlying non-alcoholic fatty liver disease (NAFLD) are not fully understood, but the gut microbiota is deeply involved. Because the Japanese traditional medicine bofutsushosan (BTS; Fangfengtongshengsan in Chinese) is known to improve obesity-induced liver injury and increase gut Akkermansia muciniphila, we evaluated its effects in a mouse model of diabetes-induced nonalcoholic steatohepatitis (NASH). Methods: Two-day-old male C57BL/6J mice were injected subcutaneously with streptozotocin and fed a high-fat diet (HFD) from 4 weeks. Between 5 and 8 weeks, HFD was supplemented with 5% BTS (BTS) or not supplemented (CONT), and plasma, liver, and stool samples were collected and analyzed. Results: The NAFLD activity score (NAS), which was consistent with early steatohepatitis in CONT mice, was significantly lower in BTS mice (P = 0.018). Improvement of steatosis contributed most to decreasing NAS. Relative abundances of probiotic Akkermansia muciniphila and Bifidobacterium pseudolongum were significantly higher in BTS mice (both P < 0.05). Positive correlations were observed among NAS, steatosis, ballooning, and body weight change. Liver macrophage markers correlated with some microbes in BTS mice. Conclusions: BTS administration suppressed liver steatosis and improved the gut microbiome, which correlated with some liver factors. BTS may be a promising treatment for NAFLD by maintaining the gut–liver axis. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2667-1425 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2667142524000836; https://doaj.org/toc/2667-1425 |
| DOI: | 10.1016/j.prmcm.2024.100440 |
| Access URL: | https://doaj.org/article/1f4dd0445daf4d9f9500eca658100bac |
| Accession Number: | edsdoj.1f4dd0445daf4d9f9500eca658100bac |
| Database: | Directory of Open Access Journals |
| ISSN: | 26671425 |
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| DOI: | 10.1016/j.prmcm.2024.100440 |
| Published in: | Pharmacological Research - Modern Chinese Medicine |
| Language: | English |