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Pharmacological studies of anti-inflammatory, anti-nociceptive and anti-pyretic compounds found in chromatographic fractions of Anogeissus leiocarpa (DC). Guill. & Perr. leaves

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Title: Pharmacological studies of anti-inflammatory, anti-nociceptive and anti-pyretic compounds found in chromatographic fractions of Anogeissus leiocarpa (DC). Guill. & Perr. leaves
Authors: Precious A. Idakwoji, Francis O. Atanu, Paul C. Nweje-Anyalowu, Theophilus B. Momoh, Wisdom O. Oniwon, Sara T. Elazab, Souty M.Z. Sharkawi, Rania M. Waheed, Amal Youssef, Gaber El-Saber Batiha
Source: Journal of Pharmacy & Pharmacognosy Research, Vol 10, Iss 3, Pp 459-468 (2022)
Publisher Information: GarVal Editorial Ltda., 2022.
Publication Year: 2022
Collection: LCC:Therapeutics. Pharmacology
LCC:Pharmacy and materia medica
Subject Terms: anogeissus leiocarpa, anti-inflammatory, antinociception, antipyretic, inflammation, nsaid, pyrexia, Therapeutics. Pharmacology, RM1-950, Pharmacy and materia medica, RS1-441
More Details: Context: The anti-nociceptive and anti-pyretic properties of the crude aqueous extract of Anogeissus leiocarpa (DC). Guill. & Perr. leaves have been reported. Aims: To investigate the anti-inflammatory, anti-nociceptive, and anti-pyretic properties of aqueous extract of A. leiocarpa leaves (AEAL) and its fractions to identify the bioactive compound(s). Methods: AEAL was fractionated successively and eluted in gradients of solvent mixture (n-hexane, ethylacetate, and methanol). Eluates, which showed similar TLC profiles were pooled to afford 5 fractions (F1-F5). AEAL and the fractions were subjected to phytochemical analysis and investigated for anti-inflammatory, anti-nociceptive, and anti-pyretic effects using carrageenan-induced paw edema and Brewer’s yeast-induced pyrexia in rats, and acetic acid-induced writhing in mouse models, respectively. Results: Phytochemical analysis indicated presence of terpenoids, saponins, steroids, glycosides, flavonoids, tannins and alkaloids. At 200 mg/kg b.w, AEAL and F1-F5 recorded significant (p
Document Type: article
File Description: electronic resource
Language: English
Spanish; Castilian
ISSN: 0719-4250
Relation: https://jppres.com/jppres/pdf/vol10/jppres21.1265_10.3.459.pdf; https://doaj.org/toc/0719-4250
Access URL: https://doaj.org/article/a1f4655adfc44d1d954ed5bf7890ac64
Accession Number: edsdoj.1f4655adfc44d1d954ed5bf7890ac64
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  Data: Pharmacological studies of anti-inflammatory, anti-nociceptive and anti-pyretic compounds found in chromatographic fractions of Anogeissus leiocarpa (DC). Guill. & Perr. leaves
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  Data: <searchLink fieldCode="AR" term="%22Precious+A%2E+Idakwoji%22">Precious A. Idakwoji</searchLink><br /><searchLink fieldCode="AR" term="%22Francis+O%2E+Atanu%22">Francis O. Atanu</searchLink><br /><searchLink fieldCode="AR" term="%22Paul+C%2E+Nweje-Anyalowu%22">Paul C. Nweje-Anyalowu</searchLink><br /><searchLink fieldCode="AR" term="%22Theophilus+B%2E+Momoh%22">Theophilus B. Momoh</searchLink><br /><searchLink fieldCode="AR" term="%22Wisdom+O%2E+Oniwon%22">Wisdom O. Oniwon</searchLink><br /><searchLink fieldCode="AR" term="%22Sara+T%2E+Elazab%22">Sara T. Elazab</searchLink><br /><searchLink fieldCode="AR" term="%22Souty+M%2EZ%2E+Sharkawi%22">Souty M.Z. Sharkawi</searchLink><br /><searchLink fieldCode="AR" term="%22Rania+M%2E+Waheed%22">Rania M. Waheed</searchLink><br /><searchLink fieldCode="AR" term="%22Amal+Youssef%22">Amal Youssef</searchLink><br /><searchLink fieldCode="AR" term="%22Gaber+El-Saber+Batiha%22">Gaber El-Saber Batiha</searchLink>
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  Data: Journal of Pharmacy & Pharmacognosy Research, Vol 10, Iss 3, Pp 459-468 (2022)
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  Data: GarVal Editorial Ltda., 2022.
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  Data: 2022
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  Data: LCC:Therapeutics. Pharmacology<br />LCC:Pharmacy and materia medica
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  Data: <searchLink fieldCode="DE" term="%22anogeissus+leiocarpa%22">anogeissus leiocarpa</searchLink><br /><searchLink fieldCode="DE" term="%22anti-inflammatory%22">anti-inflammatory</searchLink><br /><searchLink fieldCode="DE" term="%22antinociception%22">antinociception</searchLink><br /><searchLink fieldCode="DE" term="%22antipyretic%22">antipyretic</searchLink><br /><searchLink fieldCode="DE" term="%22inflammation%22">inflammation</searchLink><br /><searchLink fieldCode="DE" term="%22nsaid%22">nsaid</searchLink><br /><searchLink fieldCode="DE" term="%22pyrexia%22">pyrexia</searchLink><br /><searchLink fieldCode="DE" term="%22Therapeutics%2E+Pharmacology%22">Therapeutics. Pharmacology</searchLink><br /><searchLink fieldCode="DE" term="%22RM1-950%22">RM1-950</searchLink><br /><searchLink fieldCode="DE" term="%22Pharmacy+and+materia+medica%22">Pharmacy and materia medica</searchLink><br /><searchLink fieldCode="DE" term="%22RS1-441%22">RS1-441</searchLink>
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  Label: Description
  Group: Ab
  Data: Context: The anti-nociceptive and anti-pyretic properties of the crude aqueous extract of Anogeissus leiocarpa (DC). Guill. & Perr. leaves have been reported. Aims: To investigate the anti-inflammatory, anti-nociceptive, and anti-pyretic properties of aqueous extract of A. leiocarpa leaves (AEAL) and its fractions to identify the bioactive compound(s). Methods: AEAL was fractionated successively and eluted in gradients of solvent mixture (n-hexane, ethylacetate, and methanol). Eluates, which showed similar TLC profiles were pooled to afford 5 fractions (F1-F5). AEAL and the fractions were subjected to phytochemical analysis and investigated for anti-inflammatory, anti-nociceptive, and anti-pyretic effects using carrageenan-induced paw edema and Brewer’s yeast-induced pyrexia in rats, and acetic acid-induced writhing in mouse models, respectively. Results: Phytochemical analysis indicated presence of terpenoids, saponins, steroids, glycosides, flavonoids, tannins and alkaloids. At 200 mg/kg b.w, AEAL and F1-F5 recorded significant (p
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  Data: https://jppres.com/jppres/pdf/vol10/jppres21.1265_10.3.459.pdf; https://doaj.org/toc/0719-4250
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      – Text: English
      – Text: Spanish; Castilian
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      Pagination:
        PageCount: 10
        StartPage: 459
    Subjects:
      – SubjectFull: anogeissus leiocarpa
        Type: general
      – SubjectFull: anti-inflammatory
        Type: general
      – SubjectFull: antinociception
        Type: general
      – SubjectFull: antipyretic
        Type: general
      – SubjectFull: inflammation
        Type: general
      – SubjectFull: nsaid
        Type: general
      – SubjectFull: pyrexia
        Type: general
      – SubjectFull: Therapeutics. Pharmacology
        Type: general
      – SubjectFull: RM1-950
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      – SubjectFull: Pharmacy and materia medica
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      – SubjectFull: RS1-441
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      – TitleFull: Pharmacological studies of anti-inflammatory, anti-nociceptive and anti-pyretic compounds found in chromatographic fractions of Anogeissus leiocarpa (DC). Guill. & Perr. leaves
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            NameFull: Paul C. Nweje-Anyalowu
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            – D: 01
              M: 05
              Type: published
              Y: 2022
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