Pharmacological studies of anti-inflammatory, anti-nociceptive and anti-pyretic compounds found in chromatographic fractions of Anogeissus leiocarpa (DC). Guill. & Perr. leaves
| Title: | Pharmacological studies of anti-inflammatory, anti-nociceptive and anti-pyretic compounds found in chromatographic fractions of Anogeissus leiocarpa (DC). Guill. & Perr. leaves |
|---|---|
| Authors: | Precious A. Idakwoji, Francis O. Atanu, Paul C. Nweje-Anyalowu, Theophilus B. Momoh, Wisdom O. Oniwon, Sara T. Elazab, Souty M.Z. Sharkawi, Rania M. Waheed, Amal Youssef, Gaber El-Saber Batiha |
| Source: | Journal of Pharmacy & Pharmacognosy Research, Vol 10, Iss 3, Pp 459-468 (2022) |
| Publisher Information: | GarVal Editorial Ltda., 2022. |
| Publication Year: | 2022 |
| Collection: | LCC:Therapeutics. Pharmacology LCC:Pharmacy and materia medica |
| Subject Terms: | anogeissus leiocarpa, anti-inflammatory, antinociception, antipyretic, inflammation, nsaid, pyrexia, Therapeutics. Pharmacology, RM1-950, Pharmacy and materia medica, RS1-441 |
| More Details: | Context: The anti-nociceptive and anti-pyretic properties of the crude aqueous extract of Anogeissus leiocarpa (DC). Guill. & Perr. leaves have been reported. Aims: To investigate the anti-inflammatory, anti-nociceptive, and anti-pyretic properties of aqueous extract of A. leiocarpa leaves (AEAL) and its fractions to identify the bioactive compound(s). Methods: AEAL was fractionated successively and eluted in gradients of solvent mixture (n-hexane, ethylacetate, and methanol). Eluates, which showed similar TLC profiles were pooled to afford 5 fractions (F1-F5). AEAL and the fractions were subjected to phytochemical analysis and investigated for anti-inflammatory, anti-nociceptive, and anti-pyretic effects using carrageenan-induced paw edema and Brewer’s yeast-induced pyrexia in rats, and acetic acid-induced writhing in mouse models, respectively. Results: Phytochemical analysis indicated presence of terpenoids, saponins, steroids, glycosides, flavonoids, tannins and alkaloids. At 200 mg/kg b.w, AEAL and F1-F5 recorded significant (p |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English Spanish; Castilian |
| ISSN: | 0719-4250 |
| Relation: | https://jppres.com/jppres/pdf/vol10/jppres21.1265_10.3.459.pdf; https://doaj.org/toc/0719-4250 |
| Access URL: | https://doaj.org/article/a1f4655adfc44d1d954ed5bf7890ac64 |
| Accession Number: | edsdoj.1f4655adfc44d1d954ed5bf7890ac64 |
| Database: | Directory of Open Access Journals |
| ISSN: | 07194250 |
|---|---|
| Published in: | Journal of Pharmacy & Pharmacognosy Research |
| Language: | English Spanish; Castilian |