Academic Journal
Prostate-Specific Membrane Antigen Expression in Patients with Primary Prostate Cancer: Diagnostic and Prognostic Value in Positron Emission Tomography-Prostate-Specific Membrane Antigen
| Title: | Prostate-Specific Membrane Antigen Expression in Patients with Primary Prostate Cancer: Diagnostic and Prognostic Value in Positron Emission Tomography-Prostate-Specific Membrane Antigen |
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| Authors: | Omar Tayara, Sławomir Poletajew, Wojciech Malewski, Jolanta Kunikowska, Kacper Pełka, Piotr Kryst, Łukasz Nyk |
| Source: | Current Oncology, Vol 31, Iss 8, Pp 4165-4177 (2024) |
| Publisher Information: | MDPI AG, 2024. |
| Publication Year: | 2024 |
| Collection: | LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| Subject Terms: | prostate-specific antigen (PSA), prostate-specific membrane antigen (PSMA), positron emission tomography (PET), computed tomography (CT), magnetic resonance imaging (MRI), Food and Drug Administration (FDA), Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| More Details: | Prostate cancer represents a significant public health challenge, with its management requiring precise diagnostic and prognostic tools. Prostate-specific membrane antigen (PSMA), a cell surface enzyme overexpressed in prostate cancer cells, has emerged as a pivotal biomarker. PSMA’s ability to increase the sensitivity of PET imaging has revolutionized its application in the clinical management of prostate cancer. The advancements in PET-PSMA imaging technologies and methodologies, including the development of PSMA-targeted radiotracers and optimized imaging protocols, led to diagnostic accuracy and clinical utility across different stages of prostate cancer. This highlights its superiority in staging and its comparative effectiveness against conventional imaging modalities. This paper analyzes the impact of PET-PSMA on prostate cancer management, discussing the existing challenges and suggesting future research directions. The integration of recent studies and reviews underscores the evolving understanding of PET-PSMA imaging, marking its significant but still expanding role in clinical practice. This comprehensive review serves as a crucial resource for clinicians and researchers involved in the multifaceted domains of prostate cancer diagnosis, treatment, and management. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 1718-7729 1198-0052 |
| Relation: | https://www.mdpi.com/1718-7729/31/8/311; https://doaj.org/toc/1198-0052; https://doaj.org/toc/1718-7729 |
| DOI: | 10.3390/curroncol31080311 |
| Access URL: | https://doaj.org/article/1f3bf3280a9b4db1ae9af92fbc19f8d5 |
| Accession Number: | edsdoj.1f3bf3280a9b4db1ae9af92fbc19f8d5 |
| Database: | Directory of Open Access Journals |
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| ISSN: | 17187729 11980052 |
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| DOI: | 10.3390/curroncol31080311 |
| Published in: | Current Oncology |
| Language: | English |