Academic Journal
Low nailfold capillary density in patients with pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension: biomarker of clinical outcome?
| Title: | Low nailfold capillary density in patients with pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension: biomarker of clinical outcome? |
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| Authors: | A. J. Smits, K. Isebia, C. Combee-Duffy, S. van der Wal, E. J. Nossent, A. Boonstra, A. Vonk-Noordegraaf, H. J. Bogaard, E. H. Serné |
| Source: | Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024) |
| Publisher Information: | Nature Portfolio, 2024. |
| Publication Year: | 2024 |
| Collection: | LCC:Medicine LCC:Science |
| Subject Terms: | Pulmonary arterial hypertension, Pulmonary hypertension, Chronic thrombo-embolic pulmonary hypertension, Nailfold-capillaroscopy, Microvascular, Diagnosis, Medicine, Science |
| More Details: | Abstract Nailfold capillary density is lower in patients with pulmonary arterial hypertension (PAH). It is unclear whether this observation signifies a unique systemic manifestation of PAH, or reflects microcirculatory dysfunction secondary to pulmonary hypertension (PH). Capillary density and loop dimensions were measured by nailfold-capillaroscopy (NC) in 30 PAH (23 idiopathic, or iPAH, 7 hereditary, or hPAH), 17 chronic thromboembolic PH (CTEPH) patients and 48 controls. NC-Measurements were repeated after pulmonary endarterectomy (PEA) or balloon pulmonary angioplasty (BPA) in CTEPH patients. We examined whether NC-measurements were related to markers of disease severity and predictive of time to clinical worsening (TTCW) as tested by univariate linear/logistic regression and cox-regression analysis, respectively. Capillary density was significantly lower in PAH (7.5 ± 1.1, p |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2045-2322 |
| Relation: | https://doaj.org/toc/2045-2322 |
| DOI: | 10.1038/s41598-024-69017-y |
| Access URL: | https://doaj.org/article/1f2f4671e8114f21b07a8e2c2eae77b0 |
| Accession Number: | edsdoj.1f2f4671e8114f21b07a8e2c2eae77b0 |
| Database: | Directory of Open Access Journals |
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| ISSN: | 20452322 |
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| DOI: | 10.1038/s41598-024-69017-y |
| Published in: | Scientific Reports |
| Language: | English |