Bibliographic Details
| Title: |
Chronic kidney disease (CKD) and associated risk in rural South Africa: a population-based cohort study [version 2; peer review: 2 approved] |
| Authors: |
F. Xavier Gómez-Olivé, Laurie A Tomlinson, June Fabian, Nokthula Mayindi, Mwawi Gondwe, Bongekile Khoza, Shingirai Chipungu, Alisha N Wade, Petra Gaylard, Stephen Tollman, Michele Ramsay, Jaya A George, Cheryl Winkler, Saraladevi Naicker |
| Source: |
Wellcome Open Research, Vol 7 (2022) |
| Publisher Information: |
Wellcome, 2022. |
| Publication Year: |
2022 |
| Collection: |
LCC:Medicine
LCC:Science |
| Subject Terms: |
chronic kidney disease, Africa, South Africa, hypertension, HIV infection, diabetes, eng, Medicine, Science |
| More Details: |
Background: In Africa, true prevalence of chronic kidney disease (CKD) is unknown, and associated clinical and genetic risk factors remain understudied. This population-based cohort study aimed to investigate CKD prevalence and associated risk factors in rural South Africa. Methods: A total 2021 adults aged 20-79 years were recruited between 2017-2018 from the Agincourt Health and Socio-Demographic Surveillance System in Bushbuckridge, Mpumalanga, South Africa. The following were collected: sociodemographic, anthropometric, and clinical data; venous blood samples for creatinine, hepatitis B serology; DNA extraction; spot urine samples for dipstick testing and urine albumin: creatinine ratio (UACR) measurement. Point-of-care screening determined prevalent HIV infection, diabetes, and hypercholesterolemia. DNA was used to test for apolipoprotein L1 (APOL1) kidney risk variants. Kidney Disease Improving Global Outcomes (KDIGO) criteria were used to diagnose CKD as low eGFR ( |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2398-502X |
| Relation: |
https://wellcomeopenresearch.org/articles/7-236/v2; https://doaj.org/toc/2398-502X |
| DOI: |
10.12688/wellcomeopenres.18016.2 |
| Access URL: |
https://doaj.org/article/1f022b7c26a14a878307f16cec55208f |
| Accession Number: |
edsdoj.1f022b7c26a14a878307f16cec55208f |
| Database: |
Directory of Open Access Journals |
