Comprehensive and updated review on anti-oxidant effects of Nigella sativa and its constituent, thymoquinone, in various disorders
| Title: | Comprehensive and updated review on anti-oxidant effects of Nigella sativa and its constituent, thymoquinone, in various disorders |
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| Authors: | Mohammad Reza Aslani, Saeideh Saadat, Mohammad Hossein Boskabady |
| Source: | Iranian Journal of Basic Medical Sciences, Vol 27, Iss 8, Pp 923-951 (2024) |
| Publisher Information: | Mashhad University of Medical Sciences, 2024. |
| Publication Year: | 2024 |
| Collection: | LCC:Medicine |
| Subject Terms: | anti-oxidants, essential oil, plant extracts, nigella sativa, oxidative stress, thymoquinone, Medicine |
| More Details: | Several pharmacological effects were described for Nigella sativa (N. sativa) seed and it has been used traditionally to treat various diseases. In this review article, the updated and comprehensive anti-oxidant effects of N. sativa and its main constituent, thymoquinone (TQ), on various disorders are described. The relevant articles were retrieved through PubMed, Science Direct, and Scopus up to December 31, 2023. Various extracts and essential oils of N. sativa showed anti-oxidant effects on cardiovascular, endocrine, gastrointestinal and liver, neurologic, respiratory, and urogenital diseases by decreasing and increasing various oxidant and anti-oxidant marketers, respectively. The main constituent of the plant, TQ, also showed similar anti-oxidant effects as the plant itself. The anti-oxidant effects of different extracts and essential oils of N. sativa were demonstrated in various studies which were perhaps due to the main constituent of the plant, TQ. The findings of this review article suggest the possible therapeutic effect of N. sativa and TQ in oxidative stress disorders. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2008-3866 2008-3874 95261397 |
| Relation: | https://ijbms.mums.ac.ir/article_24172_487961cff44b0e44d2e97213cb312a8b.pdf; https://doaj.org/toc/2008-3866; https://doaj.org/toc/2008-3874 |
| DOI: | 10.22038/ijbms.2024.75985.16453 |
| Access URL: | https://doaj.org/article/1eecca39667c48a4bca9526139733d50 |
| Accession Number: | edsdoj.1eecca39667c48a4bca9526139733d50 |
| Database: | Directory of Open Access Journals |
| ISSN: | 20083866 20083874 95261397 |
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| DOI: | 10.22038/ijbms.2024.75985.16453 |
| Published in: | Iranian Journal of Basic Medical Sciences |
| Language: | English |