Bibliographic Details
| Title: |
Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation |
| Authors: |
Chiara Maniaci, Scott J. Hughes, Andrea Testa, Wenzhang Chen, Douglas J. Lamont, Sonia Rocha, Dario R. Alessi, Roberto Romeo, Alessio Ciulli |
| Source: |
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017) |
| Publisher Information: |
Nature Portfolio, 2017. |
| Publication Year: |
2017 |
| Collection: |
LCC:Science |
| Subject Terms: |
Science |
| More Details: |
Targeting the ubiquitin proteasome system to modulate protein homeostasis using small molecules has promising therapeutic potential. Here the authors describe Homo-PROTACS: small molecules that can induce the homo-dimerization of E3 ubiquitin ligases and cause their proteasome-dependent degradation. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2041-1723 |
| Relation: |
https://doaj.org/toc/2041-1723 |
| DOI: |
10.1038/s41467-017-00954-1 |
| Access URL: |
https://doaj.org/article/ce1eb8bbc3b24cf8a56b68d61eacff1e |
| Accession Number: |
edsdoj.1eb8bbc3b24cf8a56b68d61eacff1e |
| Database: |
Directory of Open Access Journals |
