Bibliographic Details
| Title: |
Evaluation of a population-wide, systematic screening initiative for tuberculosis on Daru island, Western Province, Papua New Guinea |
| Authors: |
Paison Dakulala, Margaret Kal, Alice Honjepari, Lucy Morris, Richard Rehan, Simon Peter Akena, Andrew J. Codlin, Narantuya Jadambaa, Tauhid Islam, Manami Yanagawa, Fukushi Morishita |
| Source: |
BMC Public Health, Vol 24, Iss 1, Pp 1-11 (2024) |
| Publisher Information: |
BMC, 2024. |
| Publication Year: |
2024 |
| Collection: |
LCC:Public aspects of medicine |
| Subject Terms: |
Tuberculosis, Screening, Papua New Guinea, Public aspects of medicine, RA1-1270 |
| More Details: |
Abstract Background A population-wide, systematic screening initiative for tuberculosis (TB) was implemented on Daru island in the Western Province of Papua New Guinea, where TB is known to be highly prevalent. The initiative used a mobile van equipped with a digital X-ray device, computer-aided detection (CAD) software to identify TB-related abnormalities on chest radiographs, and GeneXpert machines for follow-on diagnostic testing. We describe the results of the TB screening initiative, evaluate its population-level impact and examine risk factors associated with TB detection. Methods Through a retrospective review of screening data, we assessed the effectiveness of the screening by examining the enrolment coverage and the proportion of people with TB among screened subjects. A cascade analysis was performed to illustrate the flow of participants in the screening algorithm. We conducted univariate and multivariate analyses to identify factors associated with TB. Furthermore, we estimated the number of additional cases detected by the project by examining the trend of routine TB case notifications during the intervention period, compared to the historical baseline cases and trend-adjusted expected cases. Results Of the island’s 18,854 residents, 8,085 (42.9%) were enrolled and 7,970 (98.6%) had chest X-ray interpreted by the CAD4TB software. A total of 1,116 (14.0%) participants were considered to have abnormal CXR. A total of 69 Xpert-positive cases were diagnosed, resulting in a detection rate of 853 per 100 000 population screened. 19.4% of people with TB had resistance to rifampicin. People who were in older age groups (aOR 6.6, 95%CI: 1.5–29.1 for the 45–59 age group), were severely underweight (aOR 2.5, 95%CI:1.0-6.1) or underweight (aOR 2.1, 95%CI: 1.1–3.8), lived in households |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1471-2458 |
| Relation: |
https://doaj.org/toc/1471-2458 |
| DOI: |
10.1186/s12889-024-17918-y |
| Access URL: |
https://doaj.org/article/d1e8ce572ddd4d4fbf14f51718e28406 |
| Accession Number: |
edsdoj.1e8ce572ddd4d4fbf14f51718e28406 |
| Database: |
Directory of Open Access Journals |
