| Title: |
Associations between Cord Blood Leptin Levels and Childhood Adiposity Differ by Sex and Age at Adiposity Assessment |
| Authors: |
Kasandra Blais, Myriam Doyon, Mélina Arguin, Luigi Bouchard, Patrice Perron, Marie-France Hivert |
| Source: |
Life, Vol 12, Iss 12, p 2060 (2022) |
| Publisher Information: |
MDPI AG, 2022. |
| Publication Year: |
2022 |
| Collection: |
LCC:Science |
| Subject Terms: |
body mass index, childhood adiposity, cord blood leptin, dual-energy X-ray absorptiometry, sex-specific associations, skinfolds, Science |
| More Details: |
Lower cord blood leptin levels have been associated with lower and higher adiposity in childhood and associations seem to differ according to the child’s age, methods of adiposity assessment and sex. Our aim was to investigate sex-specific associations of cord blood leptinemia with childhood adiposity at birth, 3 and 5 years of age. We measured cord blood leptin using Luminex immunoassays in 520 offspring from the Gen3G cohort. We tested associations between cord blood leptin and body mass index (BMI) z-score, skinfolds thicknesses (SFT), and body composition using dual-energy X-ray absorptiometry, adjusted for confounders. At birth, girls had almost twice as much leptin in cord blood as boys (15.5 [8.9; 25.6] vs. 8.6 [4.9; 15.0] ng/mL; p < 0.0001) as well as significantly greater adiposity. Lower levels of cord blood leptin were associated with higher sum of SFT (β = −0.05 ± 0.02; p = 0.03) and higher BMI z-score (β= −0.22 ± 0.08; p = 0.01) in 3-year-old boys only. We did not observe these associations at age 5, or in girls. Our results suggest a sexual dimorphism in the programming of leptin sensitivity and childhood adiposity, but further observational and functional studies are needed to better understand the role of leptin in early life. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2075-1729 |
| Relation: |
https://www.mdpi.com/2075-1729/12/12/2060; https://doaj.org/toc/2075-1729 |
| DOI: |
10.3390/life12122060 |
| Access URL: |
https://doaj.org/article/1e719a76af04422d95c28836c16d7c66 |
| Accession Number: |
edsdoj.1e719a76af04422d95c28836c16d7c66 |
| Database: |
Directory of Open Access Journals |
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