Investigation of nerve fibers in the skin by biopsy: technical aspects, indications, and contribution to diagnosis of small-fiber neuropathy
| Title: | Investigation of nerve fibers in the skin by biopsy: technical aspects, indications, and contribution to diagnosis of small-fiber neuropathy |
|---|---|
| Authors: | Irina Raicher, Luís Henrique Casartelli Ravagnani, Silene Gomes Correa, Cristine Dobo, Cristóvão Luis Pitangueira Mangueira, Ricardo Silvestre e Silva Macarenco |
| Source: | Einstein (São Paulo), Vol 20 (2022) |
| Publisher Information: | Instituto Israelita de Ensino e Pesquisa Albert Einstein, 2022. |
| Publication Year: | 2022 |
| Collection: | LCC:Medicine |
| Subject Terms: | Biopsy, Skin, Nerve fibers, Small fiber neuropathy, Diabetes mellitus, Diabetic neuropathies, Fabry disease, Neuralgia, postherpetic, HIV, Rheumatic diseases, Drug therapy, Medicine |
| More Details: | ABSTRACT Skin biopsy with investigation of small-diameter nerve fibers in human epidermis and dermis has been proven to be a useful method for confirming small-fiber neuropathy. In medical practice, small-fiber neuropathy is increasingly recognized as a leading cause of neuropathic pain. It is a prevalent complaint in medical offices, brought by patients often as a “painful burning sensation”. The prevalence of neuropathic pain is high in small-fiber neuropathies of different etiologies, especially in the elderly; 7% of population in this age group present peripheral neuropathy. Pain and paresthesia are symptoms which might cause disability and impair quality of life of patients. The early detection of small-fiber neuropathy can contribute to reducing unhealthy lifestyles, associated to higher incidence of the disease. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English Portuguese |
| ISSN: | 2317-6385 |
| Relation: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082022000100800&tlng=en; https://doaj.org/toc/2317-6385 |
| DOI: | 10.31744/einstein_journal/2022md8044 |
| Access URL: | https://doaj.org/article/1e2001ab5d3e422a933f0354d80ed05c |
| Accession Number: | edsdoj.1e2001ab5d3e422a933f0354d80ed05c |
| Database: | Directory of Open Access Journals |
| ISSN: | 23176385 |
|---|---|
| DOI: | 10.31744/einstein_journal/2022md8044 |
| Published in: | Einstein (São Paulo) |
| Language: | English Portuguese |