Bibliographic Details
| Title: |
Present and Future Therapeutic Approaches to Barrier Dysfunction |
| Authors: |
Marina Fortea, Mercé Albert-Bayo, Mar Abril-Gil, John-Peter Ganda Mall, Xavier Serra-Ruiz, Alejandro Henao-Paez, Elba Expósito, Ana María González-Castro, Danila Guagnozzi, Beatriz Lobo, Carmen Alonso-Cotoner, Javier Santos |
| Source: |
Frontiers in Nutrition, Vol 8 (2021) |
| Publisher Information: |
Frontiers Media S.A., 2021. |
| Publication Year: |
2021 |
| Collection: |
LCC:Nutrition. Foods and food supply |
| Subject Terms: |
epithelial barrier function, intestinal permeability, nutrients, short chain fatty acids, prebiotics, probiotics, Nutrition. Foods and food supply, TX341-641 |
| More Details: |
There is converging and increasing evidence, but also uncertainty, for the role of abnormal intestinal epithelial barrier function in the origin and development of a growing number of human gastrointestinal and extraintestinal inflammatory disorders, and their related complaints. Despite a vast literature addressing factors and mechanisms underlying changes in intestinal permeability in humans, and its connection to the appearance and severity of clinical symptoms, the ultimate link remains to be established in many cases. Accordingly, there are no directives or clinical guidelines related to the therapeutic management of intestinal permeability disorders that allow health professionals involved in the management of these patients to carry out a consensus treatment based on clinical evidence. Instead, there are multiple pseudoscientific approaches and commercial propaganda scattered on the internet that confuse those affected and health professionals and that often lack scientific rigor. Therefore, in this review we aim to shed light on the different therapeutic options, which include, among others, dietary management, nutraceuticals and medical devices, microbiota and drugs, and epigenetic and exosomes-manipulation, through an objective evaluation of the scientific publications in this field. Advances in the knowledge and management of intestinal permeability will sure enable better options of dealing with this group of common disorders to enhance quality of life of those affected. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2296-861X |
| Relation: |
https://www.frontiersin.org/articles/10.3389/fnut.2021.718093/full; https://doaj.org/toc/2296-861X |
| DOI: |
10.3389/fnut.2021.718093 |
| Access URL: |
https://doaj.org/article/a1dd4c518c14408fad0d10b4c73bb96a |
| Accession Number: |
edsdoj.1dd4c518c14408fad0d10b4c73bb96a |
| Database: |
Directory of Open Access Journals |
