Academic Journal
High precision acoustofluidic synthesis of stable, biocompatible water-in-water emulsions
| Title: | High precision acoustofluidic synthesis of stable, biocompatible water-in-water emulsions |
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| Authors: | Kajal Sharma, Hao Deng, Parikshit Banerjee, Zaimao Peng, Jackson Gum, Alberto Baldelli, Jacek Jasieniak, Laurence Meagher, Mikaël M. Martino, Venkat Gundabala, Tuncay Alan |
| Source: | Ultrasonics Sonochemistry, Vol 111, Iss , Pp 107120- (2024) |
| Publisher Information: | Elsevier, 2024. |
| Publication Year: | 2024 |
| Collection: | LCC:Chemistry LCC:Acoustics. Sound |
| Subject Terms: | Aqueous two-phase systems, Water-in-water emulsions, Microfluidic mixer, Acoustofluidics, Emulsion encapsulation, Chemistry, QD1-999, Acoustics. Sound, QC221-246 |
| More Details: | Water-in-water (w/w) emulsions, comprising aqueous droplets within another continuous aqueous phase, rely on a low interfacial tension for stability. Thus far, it has been challenging to control their size and stability without the use of stabilizers. In this study, we introduce a microfluidic technique that addresses these challenges, producing stable w/w emulsions with precisely controlled size and uniformity. Results shows that using an acoustically actuated microfluidic mixer, PEG, Dextran, and alginate solutions (84.66 mPa.s viscosity difference) were homogenized rapidly, forming uniformly distributed w/w emulsions stabilized in alginate gels.The emulsion size, uniformity, and shear sensitivity can be tuned by modifying the alginate concentration. Biocompatibility was evaluated by monitoring the viability of kidney cells in the presence of emulsions and gels. In conclusion, this study not only showed emulsion formation with a high mixing efficiency exceeding 90 % for all viscosities, actuated at an optimized frequency of 1.064 MHz, but also demonstrated that an aqueous, solvent, and emulsifier-free composition exhibited remarkable biocompatibility, holding promise for precise drug delivery, cosmetics, and food applications. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 1350-4177 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S1350417724003687; https://doaj.org/toc/1350-4177 |
| DOI: | 10.1016/j.ultsonch.2024.107120 |
| Access URL: | https://doaj.org/article/1da6be8cb9134f2cae65eb6a36d60415 |
| Accession Number: | edsdoj.1da6be8cb9134f2cae65eb6a36d60415 |
| Database: | Directory of Open Access Journals |
| ISSN: | 13504177 |
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| DOI: | 10.1016/j.ultsonch.2024.107120 |
| Published in: | Ultrasonics Sonochemistry |
| Language: | English |