GENETIC SYMPHONY: INVESTIGATING CODON USAGE BIAS AND EVOLUTIONARY DYNAMICS IN WEST NILE VIRUS ACROSS DIVERSE GEOGRAPHICAL REGIONS
| Title: | GENETIC SYMPHONY: INVESTIGATING CODON USAGE BIAS AND EVOLUTIONARY DYNAMICS IN WEST NILE VIRUS ACROSS DIVERSE GEOGRAPHICAL REGIONS |
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| Authors: | Swati Rani, Varsha Ramesh, Mallikarjun S Beelagi, Raaga R, Kuralayanapalya Puttahonnappa Suresh, Nagendra Nath Barman, Sharanagouda S Patil |
| Source: | Exploratory Animal and Medical Research, Vol 14, Iss 2, Pp 187-200 (2024) |
| Publisher Information: | West Bengal Veterinary Alumni Association, 2024. |
| Publication Year: | 2024 |
| Collection: | LCC:Veterinary medicine |
| Subject Terms: | codon usage bias, west nile virus, evolutionary dynamics, phytogeography analysis, tmrca, epidemiological analysis, Veterinary medicine, SF600-1100 |
| More Details: | West Nile Virus (WNV) infection, a significant zoonotic disease caused by Flaviviruses, affects birds, humans, and other wildlife species, leading to mild to severe fever and sometimes fatal neuroinvasive disease. Since its discovery, WNV has triggered epidemics on every continent except Antarctica, leading to significant financial losses from treatment costs, control programs, and the loss of animals and their products. The absence of specialized antiviral therapies or effective vaccines contributes to ongoing outbreaks in both endemic and non-endemic regions. This study combines analyses of codon usage bias, evolutionary dynamics, and phylogeography of WNV across Africa, America, Asia, and Europe. Results indicate that mutational pressure and natural selection shape codon usage bias, with natural selection being the primary driving force. Evolutionary dynamic analysis identified Uganda (Africa), China (Asia), Connecticut (United States of America), and Russia (Europe) as significant regions, with the tMRCA dated to 1908, 1785, 1852, and 1785, respectively. The highest evolutionary rate was observed in America, with a mean rate of 6.498E-2. These findings highlight key regions and evolutionary mechanisms driving WNV spread, essential for targeted surveillance and intervention. The study informs the development of specialized antiviral therapies and vaccines to mitigate WNV outbreaks globally. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2277-470X 2319-247X |
| Relation: | https://animalmedicalresearch.org/Vol.14_Issue-2_December_2024/GENETIC%20SYMPHONY%20-%20INVESTIGATING%20CODON%20USAGE%20BIAS%20AND%20EVOLUTIONARY.pdf; https://doaj.org/toc/2277-470X; https://doaj.org/toc/2319-247X |
| DOI: | 10.52635/eamr/14.2.187-200 |
| Access URL: | https://doaj.org/article/1d486fe932d64f94a0a45ff248d81591 |
| Accession Number: | edsdoj.1d486fe932d64f94a0a45ff248d81591 |
| Database: | Directory of Open Access Journals |
| ISSN: | 2277470X 2319247X |
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| DOI: | 10.52635/eamr/14.2.187-200 |
| Published in: | Exploratory Animal and Medical Research |
| Language: | English |