C/EBPβ converts bovine fibroblasts to adipocytes without hormone cocktail induction

Bibliographic Details
Title:	C/EBPβ converts bovine fibroblasts to adipocytes without hormone cocktail induction
Authors:	Gong Cheng, Sayed Haidar Abbas Raza, Rajwali Khan, Hong Wang, Abdullah F. Shater, Zuhair M. Mohammedsaleh, Li Wang, Yuan Tian, Feng Long, Linsen Zan
Source:	Electronic Journal of Biotechnology, Vol 52, Iss , Pp 67-75 (2021)
Publisher Information:	Elsevier, 2021.
Publication Year:	2021
Collection:	LCC:Biotechnology LCC:Biology (General)
Subject Terms:	Adipogenesis, Adipogenic genes, C/EBPβ, Cattle, Fibroblasts, Fibrogenesis, Biotechnology, TP248.13-248.65, Biology (General), QH301-705.5
More Details:	Background: Adipogenesis and fibrogenesis can be considered as a competitive process in muscle, which may affect the intramuscular fat deposition. The CCAAT/enhancer-binding protein beta (C/EBPβ) plays an important role in adipogenesis, which is well-characterized in mice, but little known in bovine so far. Results: In this study, real-time qPCR revealed that the level of C/EBPβ was increased during the developmental stages of bovine and adipogenesis process of preadipocytes. Overexpression of C/EBPβ promoted bovine fibroblast proliferation through mitotic clonal expansion (MCE), a necessary process for initiating adipogenesis, by significantly downregulating levels of p21 and p27 (p
Document Type:	article
File Description:	electronic resource
Language:	English
ISSN:	0717-3458
Relation:	http://www.sciencedirect.com/science/article/pii/S0717345821000233; https://doaj.org/toc/0717-3458
DOI:	10.1016/j.ejbt.2021.04.008
Access URL:	https://doaj.org/article/cc1cf8dba5b74a9687d45d17250026ed
Accession Number:	edsdoj.1cf8dba5b74a9687d45d17250026ed
Database:	Directory of Open Access Journals

More Details
ISSN:	07173458
DOI:	10.1016/j.ejbt.2021.04.008
Published in:	Electronic Journal of Biotechnology
Language:	English