Analysis of clinical phenotypes of neuropathic symptoms in patients with type 2 diabetes: A multicenter study
| Title: | Analysis of clinical phenotypes of neuropathic symptoms in patients with type 2 diabetes: A multicenter study |
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| Authors: | Yu Ji Kim, Jeong Min Lee, Chang Won Lee, Choon Hee Chung, Jae Hyuk Lee, Seung Hyun Ko, Dong Hyeok Cho, Ji Hyun Lee, Ho Chan Cho, Sang Soo Kim, Chong Hwa Kim, Jong Chul Won, Tae Sun Park |
| Source: | Journal of Diabetes Investigation, Vol 13, Iss 11, Pp 1852-1860 (2022) |
| Publisher Information: | Wiley, 2022. |
| Publication Year: | 2022 |
| Collection: | LCC:Diseases of the endocrine glands. Clinical endocrinology |
| Subject Terms: | Diabetes mellitus, type 2, Diabetic neuropathies, Phenotype, Diseases of the endocrine glands. Clinical endocrinology, RC648-665 |
| More Details: | Abstract Aims/Introduction We investigated the classification of diabetic peripheral neuropathy (DPN) patients by subjective symptoms, and identification of the relationship between the patterns and intensities of symptoms and the clustered groups of DPN patients. Materials and Methods This multicenter study analyzed epidemiological data and sensory symptoms of 649 patients with DPN. Cluster analysis was carried out to identify subgroups of patients with characteristic symptom profiles. Factor analysis was carried out to investigate the symptom patterns of the clustered groups of DPN patients. Results Three clusters of patients with DPN were identified: severe symptoms with decreased quality of life (cluster 1, n = 119, 18.3%), predominantly insensate symptoms with relatively good quality of life (cluster 2, n = 318, 49.0%), and moderate pain intensity and decreased quality of life (cluster 3, n = 204, 31.4%). The frequency of symptoms on each item of the Michigan Neuropathy Screening Instrument questionnaire showed a similar distribution according to pain intensities along with the three clusters. Conclusions Our study supports the hypothesis that diversity in sensory symptoms exists in patients with DPN. Heterogeneity in DPN patients should be taken into account for a more stratified or individualized treatment approach. Based on a multicenter study, we identified three clusters of patients with DPN. Our research supports the hypothesis that diversity in sensory symptoms exists in patients with DPN. Heterogeneity in DPN patients should be taken into account for a more stratified or individualized treatment approach. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2040-1124 2040-1116 20401493 |
| Relation: | https://doaj.org/toc/2040-1116; https://doaj.org/toc/2040-1124 |
| DOI: | 10.1111/jdi.13880 |
| Access URL: | https://doaj.org/article/1cbc2d0e7e20401493716a7e805b860a |
| Accession Number: | edsdoj.1cbc2d0e7e20401493716a7e805b860a |
| Database: | Directory of Open Access Journals |
| ISSN: | 20401124 20401116 20401493 |
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| DOI: | 10.1111/jdi.13880 |
| Published in: | Journal of Diabetes Investigation |
| Language: | English |