Academic Journal
Cerebro-cerebellar connectivity is increased in primary lateral sclerosis
| Title: | Cerebro-cerebellar connectivity is increased in primary lateral sclerosis |
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| Authors: | Avner Meoded, Arthur E. Morrissette, Rohan Katipally, Olivia Schanz, Stephen J. Gotts, Mary Kay Floeter |
| Source: | NeuroImage: Clinical, Vol 7, Iss C, Pp 288-296 (2015) |
| Publisher Information: | Elsevier, 2015. |
| Publication Year: | 2015 |
| Collection: | LCC:Computer applications to medicine. Medical informatics LCC:Neurology. Diseases of the nervous system |
| Subject Terms: | Motor neuron disease, Resting state functional MRI, Connectivity, Cerebellum, Primary lateral sclerosis, Computer applications to medicine. Medical informatics, R858-859.7, Neurology. Diseases of the nervous system, RC346-429 |
| More Details: | Increased functional connectivity in resting state networks was found in several studies of patients with motor neuron disorders, although diffusion tensor imaging studies consistently show loss of white matter integrity. To understand the relationship between structural connectivity and functional connectivity, we examined the structural connections between regions with altered functional connectivity in patients with primary lateral sclerosis (PLS), a long-lived motor neuron disease. Connectivity matrices were constructed from resting state fMRI in 16 PLS patients to identify areas of differing connectivity between patients and healthy controls. Probabilistic fiber tracking was used to examine structural connections between regions of differing connectivity. PLS patients had 12 regions with increased functional connectivity compared to controls, with a predominance of cerebro-cerebellar connections. Increased functional connectivity was strongest between the cerebellum and cortical motor areas and between the cerebellum and frontal and temporal cortex. Fiber tracking detected no difference in connections between regions with increased functional connectivity. We conclude that functional connectivity changes are not strongly based in structural connectivity. Increased functional connectivity may be caused by common inputs, or by reduced selectivity of cortical activation, which could result from loss of intracortical inhibition when cortical afferents are intact. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2213-1582 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2213158214001946; https://doaj.org/toc/2213-1582 |
| DOI: | 10.1016/j.nicl.2014.12.009 |
| Access URL: | https://doaj.org/article/1c7ee482f3a34acfaf8cf04a23172793 |
| Accession Number: | edsdoj.1c7ee482f3a34acfaf8cf04a23172793 |
| Database: | Directory of Open Access Journals |
| ISSN: | 22131582 |
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| DOI: | 10.1016/j.nicl.2014.12.009 |
| Published in: | NeuroImage: Clinical |
| Language: | English |