Academic Journal
A clinical study of non-bioartificial liver DPMAES support system in hepatitis B-related acute-on-chronic liver failure
| Title: | A clinical study of non-bioartificial liver DPMAES support system in hepatitis B-related acute-on-chronic liver failure |
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| Authors: | Xianwen Cheng, Yanrong Zhan, YaoShun Liu, Xia Zeng, Zhendong Wang, Feng Wang, Ya Mao, Song Na |
| Source: | Scientific Reports, Vol 14, Iss 1, Pp 1-7 (2024) |
| Publisher Information: | Nature Portfolio, 2024. |
| Publication Year: | 2024 |
| Collection: | LCC:Medicine LCC:Science |
| Subject Terms: | Medicine, Science |
| More Details: | Abstract This study aims to observe the clinical efficacy of the dual plasma molecular adsorption exchange system (DPMAES) in patients with hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF), with a focus on its regulatory effect on cytokine storm. A total of 60 HBV-ACLF patients were enrolled in this study. The observation group, comprising 30 patients, received DPMAES treatment, while the control group underwent PE treatment. We compared the efficacy changes between the two groups post-treatment. A total of 55 HBV-ACLF patients who completed the study were analyzed, Patients treated with DPMAES showed significant improvements in clinical outcomes. After DPMAES treatment, HBV-ACLF patients exhibited notably 90 day survival rate increased by 18% compared to those in the PE group. Moreover, total bilirubin levels decreased markedly, albumin and platelet levels increased compared to the PE group. After DPMAES treatment, the patient showed a significant decrease in inflammatory cytokine IL-6 (t = 5.046, P |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2045-2322 |
| Relation: | https://doaj.org/toc/2045-2322 |
| DOI: | 10.1038/s41598-024-52206-0 |
| Access URL: | https://doaj.org/article/1c645b5fa20741358d2eda48ca507914 |
| Accession Number: | edsdoj.1c645b5fa20741358d2eda48ca507914 |
| Database: | Directory of Open Access Journals |
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| ISSN: | 20452322 |
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| DOI: | 10.1038/s41598-024-52206-0 |
| Published in: | Scientific Reports |
| Language: | English |