Torsade de pointes: A nested case–control study in an integrated healthcare delivery system
| Title: | Torsade de pointes: A nested case–control study in an integrated healthcare delivery system |
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| Authors: | Neha Mantri, Meng Lu, Jonathan G. Zaroff, Neil Risch, Thomas Hoffmann, Akinyemi Oni‐Orisan, Catherine Lee, Carlos Iribarren |
| Source: | Annals of Noninvasive Electrocardiology, Vol 27, Iss 1, Pp n/a-n/a (2022) |
| Publisher Information: | Wiley, 2022. |
| Publication Year: | 2022 |
| Collection: | LCC:Diseases of the circulatory (Cardiovascular) system |
| Subject Terms: | case, control study, long QT syndrome, risk factors, torsade de pointes, Diseases of the circulatory (Cardiovascular) system, RC666-701 |
| More Details: | Abstract Background TdP is a form of polymorphic ventricular tachycardia which develops in the setting of a prolonged QT interval. There are limited data describing risk factors, treatment, and outcomes of this potentially fatal arrhythmia. Objective Our goals were as follows: (1) to validate cases presenting with Torsade de Pointes (TdP), (2) to identify modifiable risk factors, and (3) to describe the management strategies used for TdP and its prognosis in a real‐world healthcare setting. Methods Case–control study (with 2:1 matching on age, sex, and race/ethnicity) nested within the Genetic Epidemiology Research on Aging (GERA) cohort. Follow‐up of the cohort for case ascertainment was between January 01, 2005 and December 31, 2018. Results A total of 56 cases of TdP were confirmed (incidence rate = 3.6 per 100,000 persons/years). The average (SD) age of the TdP cases was 74 (13) years, 55 percent were female, and 16 percent were non‐white. The independent predictors of TdP were potassium concentration 480 ms (OR = 4.4) and prior history of coronary artery disease (OR = 2.6). Exposure to furosemide and amiodarone was significantly greater in cases than in controls. The most common treatment for TdP was IV magnesium (78.6%) and IV potassium repletion (73.2%). The in‐hospital and 1‐year mortality rates for TdP cases were 10.7% and 25.0% percent, respectively. Conclusions These findings may inform quantitative multivariate risk indices for the prediction of TdP and could guide practitioners on which patients may qualify for continuous ECG monitoring and/or electrolyte replacement therapy. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 1542-474X 1082-720X |
| Relation: | https://doaj.org/toc/1082-720X; https://doaj.org/toc/1542-474X |
| DOI: | 10.1111/anec.12888 |
| Access URL: | https://doaj.org/article/1c61a7d68c664623a160ec22860fc057 |
| Accession Number: | edsdoj.1c61a7d68c664623a160ec22860fc057 |
| Database: | Directory of Open Access Journals |
| ISSN: | 1542474X 1082720X |
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| DOI: | 10.1111/anec.12888 |
| Published in: | Annals of Noninvasive Electrocardiology |
| Language: | English |