| Title: |
STAMBPL1/TRIM21 Balances AXL Stability Impacting Mesenchymal Phenotype and Immune Response in KIRC |
| Authors: |
Shiyu Huang, Xuke Qin, Shujie Fu, Juncheng Hu, Zhengyu Jiang, Min Hu, Banghua Zhang, Jiachen Liu, Yujie Chen, Minghui Wang, Xiuheng Liu, Zhiyuan Chen, Lei Wang |
| Source: |
Advanced Science, Vol 12, Iss 1, Pp n/a-n/a (2025) |
| Publisher Information: |
Wiley, 2025. |
| Publication Year: |
2025 |
| Collection: |
LCC:Science |
| Subject Terms: |
immunotherapy resistance, kidney renal clear cell carcinoma, mesenchymal phenotype, STAM binding protein like 1, ubiquitination, Science |
| More Details: |
Abstract Kidney renal clear cell carcinoma (KIRC) is recognized as an immunogenic tumor, and immunotherapy is incorporated into its treatment landscape for decades. The acquisition of a tumor mesenchymal phenotype through epithelial‐to‐mesenchymal transition (EMT) is associated with immune evasion and can contribute to immunotherapy resistance. Here, the involvement of STAM Binding Protein Like 1 (STAMBPL1) is reported in the development of mesenchymal and immune evasion phenotypes in KIRC cells. Mechanistically, STAMBPL1 elevated protein abundance and surface accumulation of TAM Receptor AXL through diminishing the TRIM21‐mediated K63‐linked ubiquitination and subsequent lysosomal degradation of AXL, thereby enhancing the expression of mesenchymal genes while suppressing chemokines CXCL9/10 and HLA/B/C. In addition, STAMBPL1 enhanced PD‐L1 transcription via facilitating nuclear translocation of p65, and knockdown (KD) of STAMBPL1 augmented antitumor effects of PD‐1 blockade. Furthermore, STAMBPL1 silencing and the tyrosine kinase inhibitor (TKI) sunitinib also exhibited a synergistic effect on the suppression of KIRC. Collectively, targeting the STAMBPL1/TRIM21/AXL axis can decrease mesenchymal phenotype and potentiate anti‐tumor efficacy of cancer therapy. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2198-3844 |
| Relation: |
https://doaj.org/toc/2198-3844 |
| DOI: |
10.1002/advs.202405083 |
| Access URL: |
https://doaj.org/article/ae1c584a21b046b58ee18a2566313123 |
| Accession Number: |
edsdoj.1c584a21b046b58ee18a2566313123 |
| Database: |
Directory of Open Access Journals |
