Bibliographic Details
| Title: |
Mitochondrial quality control in human health and disease |
| Authors: |
Bo-Hao Liu, Chen-Zhen Xu, Yi Liu, Zi-Long Lu, Ting-Lv Fu, Guo-Rui Li, Yu Deng, Guo-Qing Luo, Song Ding, Ning Li, Qing Geng |
| Source: |
Military Medical Research, Vol 11, Iss 1, Pp 1-59 (2024) |
| Publisher Information: |
BMC, 2024. |
| Publication Year: |
2024 |
| Collection: |
LCC:Medicine (General)
LCC:Military Science |
| Subject Terms: |
Mitochondrial quality control, Metabolism, Programmed cell death, Cancer, Cardiovascular disease, Metabolic disease, Medicine (General), R5-920, Military Science |
| More Details: |
Abstract Mitochondria, the most crucial energy-generating organelles in eukaryotic cells, play a pivotal role in regulating energy metabolism. However, their significance extends beyond this, as they are also indispensable in vital life processes such as cell proliferation, differentiation, immune responses, and redox balance. In response to various physiological signals or external stimuli, a sophisticated mitochondrial quality control (MQC) mechanism has evolved, encompassing key processes like mitochondrial biogenesis, mitochondrial dynamics, and mitophagy, which have garnered increasing attention from researchers to unveil their specific molecular mechanisms. In this review, we present a comprehensive summary of the primary mechanisms and functions of key regulators involved in major components of MQC. Furthermore, the critical physiological functions regulated by MQC and its diverse roles in the progression of various systemic diseases have been described in detail. We also discuss agonists or antagonists targeting MQC, aiming to explore potential therapeutic and research prospects by enhancing MQC to stabilize mitochondrial function. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2054-9369 |
| Relation: |
https://doaj.org/toc/2054-9369 |
| DOI: |
10.1186/s40779-024-00536-5 |
| Access URL: |
https://doaj.org/article/1c3b4e5347e3408ea967f48f3614277d |
| Accession Number: |
edsdoj.1c3b4e5347e3408ea967f48f3614277d |
| Database: |
Directory of Open Access Journals |
