Postoperative CEA is a better prognostic marker than CA19-9, hCGβ or TATI after resection of colorectal liver metastases

Bibliographic Details
Title:	Postoperative CEA is a better prognostic marker than CA19-9, hCGβ or TATI after resection of colorectal liver metastases
Authors:	Reetta Peltonen, Pia Österlund, Marko Lempinen, Arno Nordin, Ulf-Håkan Stenman, Helena Isoniemi
Source:	Tumor Biology, Vol 40 (2018)
Publisher Information:	IOS Press, 2018.
Publication Year:	2018
Collection:	LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Subject Terms:	Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
More Details:	Liver metastases of colorectal cancer can be operated with a curative intent in selected cases. However, more than half of the patients have a recurrence. The aim of this study was to evaluate the prognostic and predictive value of carcinoembryonic antigen (CEA), carbohydrate antigen 19-9 (CA19-9), human chorionic gonadotropin β (hCGβ) and tumour-associated trypsin-inhibitor (TATI) in colorectal cancer patients before and 3 months after resection of liver metastases. Marker concentrations were determined in blood samples from 168 colorectal cancer patients, who underwent liver resection between the years 1998 and 2007 at Helsinki University Hospital, Finland. The samples were taken before and 3 months after curative resection. Increased concentrations of CEA (>5 µg/L) and hCGβ (>1 pmol/L) 3 months after liver resection correlated with recurrence and impaired overall survival and increased CA19-9 (>26 kU/L) with impaired overall survival, but postoperative TATI was not prognostic. Preoperatively elevated CEA and CA19-9 correlated with impaired overall survival, but not with recurrence. Neither preoperative hCGβ nor TATI was prognostic. In conclusion, CEA is a useful prognostic marker, when measured 3 months after resection of colorectal liver metastases. CA19-9 also has prognostic significance and may have additional value.
Document Type:	article
File Description:	electronic resource
Language:	English
ISSN:	1423-0380 10104283
Relation:	https://doaj.org/toc/1423-0380
DOI:	10.1177/1010428317752944
Access URL:	https://doaj.org/article/1c2a1493b4314e6c95e69a5fc3eb02fc
Accession Number:	edsdoj.1c2a1493b4314e6c95e69a5fc3eb02fc
Database:	Directory of Open Access Journals

More Details
ISSN:	14230380 10104283
DOI:	10.1177/1010428317752944
Published in:	Tumor Biology
Language:	English