| Title: |
Immune Gene Expression Profiling in Individuals with Turner Syndrome, Graves’ Disease, and a Healthy Female by Single-Cell RNA Sequencing: A Comparative Study |
| Authors: |
Soo Yeun Sim, In-Cheol Baek, Won Kyoung Cho, Min Ho Jung, Tai-Gyu Kim, Byung-Kyu Suh |
| Source: |
Cells, Vol 14, Iss 2, p 93 (2025) |
| Publisher Information: |
MDPI AG, 2025. |
| Publication Year: |
2025 |
| Collection: |
LCC:Cytology |
| Subject Terms: |
Turner syndrome, X chromosome inactivation, autoimmunity, gene expression, single-cell RNA analysis, Cytology, QH573-671 |
| More Details: |
Turner syndrome (TS) can be determined by karyotype analysis, marked by the loss of one X chromosome in females. However, the genes involved in autoimmunity in TS patients remain unclear. In this study, we aimed to analyze differences in immune gene expression between a patient with TS, a healthy female, and a female patient with Graves’ disease using single-cell RNA sequencing (scRNA-seq) analysis of antigen-specific CD4(+) T cells. We identified 43 differentially expressed genes in the TS patient compared with the healthy female and the female patient with Graves’ disease. Many of these genes have previously been suggested to play a role in immune system regulation. This study provides valuable insights into the differences in immune-related gene expression between TS patients, healthy individuals, and those with autoimmune diseases. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2073-4409 |
| Relation: |
https://www.mdpi.com/2073-4409/14/2/93; https://doaj.org/toc/2073-4409 |
| DOI: |
10.3390/cells14020093 |
| Access URL: |
https://doaj.org/article/1bb5d6c008024119a0b4d41e306d9b49 |
| Accession Number: |
edsdoj.1bb5d6c008024119a0b4d41e306d9b49 |
| Database: |
Directory of Open Access Journals |
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