Bibliographic Details
| Title: |
Aortic pathology from protein kinase G activation is prevented by an antioxidant vitamin B12 analog |
| Authors: |
Gerburg K. Schwaerzer, Hema Kalyanaraman, Darren E. Casteel, Nancy D. Dalton, Yusu Gu, Seunghoe Lee, Shunhui Zhuang, Nisreen Wahwah, Jan M. Schilling, Hemal H. Patel, Qian Zhang, Ayako Makino, Dianna M. Milewicz, Kirk L. Peterson, Gerry R. Boss, Renate B. Pilz |
| Source: |
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019) |
| Publisher Information: |
Nature Portfolio, 2019. |
| Publication Year: |
2019 |
| Collection: |
LCC:Science |
| Subject Terms: |
Science |
| More Details: |
Individuals carrying a gain-of-function mutation in PKG1 develop thoracic aortic aneurysms and dissections. Here Schwaerzer et al. show that mice carrying the same mutation recapitulate the human disease, and find that treatment with anti-oxidants including cobinamide, a vitamin B12 analog, prevents disease progression. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2041-1723 |
| Relation: |
https://doaj.org/toc/2041-1723 |
| DOI: |
10.1038/s41467-019-11389-1 |
| Access URL: |
https://doaj.org/article/1bb1d770c1fc4afd9a8c4a6eaa023c6b |
| Accession Number: |
edsdoj.1bb1d770c1fc4afd9a8c4a6eaa023c6b |
| Database: |
Directory of Open Access Journals |
