Bibliographic Details
| Title: |
Case Report: An Unusual Course of Angiosarcoma After Lung Transplantation |
| Authors: |
Saskia Bos, Liesbeth Daniëls, Lucienne Michaux, Isabelle Vanden Bempt, Sascha Vermeer, FJ Sherida H Woei-A-Jin, Patrick Schöffski, Birgit Weynand, Raf Sciot, Sabine Declercq, Laurens J. Ceulemans, Laurent Godinas, Geert M. Verleden, Dirk E. Van Raemdonck, Lieven J. Dupont, Robin Vos, the Leuven Lung Transplant Group, Jonas Yserbyt, Arne P. Neyrinck, Veronique Schaevers, Bruno Desschans, Dirk Claes, Karen Denaux, Paul De Leyn, Herbert Decaluwé, Hans Van Veer, Lieven Depypere, Marie-Paule Emonds |
| Source: |
Frontiers in Immunology, Vol 12 (2022) |
| Publisher Information: |
Frontiers Media S.A., 2022. |
| Publication Year: |
2022 |
| Collection: |
LCC:Immunologic diseases. Allergy |
| Subject Terms: |
donor-related, lung transplantation, malignancy, case report, angiosarcoma, Immunologic diseases. Allergy, RC581-607 |
| More Details: |
A 35-year-old woman underwent bilateral lung transplantation for primary ciliary dyskinesia and developed vascular tumors over a slow time course. Initial presentation of non-specific vascular tumors in the lungs and liver for up to 6 years after transplantation evolved toward bilateral ovarian angiosarcoma. Tumor analysis by haplotyping and human leukocyte antigen typing showed mixed donor chimerism, proving donor origin of the tumoral lesions. In retrospect, the donor became brain dead following neurosurgical complications for a previously biopsy-proven cerebral hemangioma, which is believed to have been a precursor lesion of the vascular malignancy in the recipient. Donor-transmitted tumors should always be suspected in solid organ transplant recipients in case of uncommon disease course or histology, and proper tissue-based diagnosis using sensitive techniques should be pursued. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1664-3224 |
| Relation: |
https://www.frontiersin.org/articles/10.3389/fimmu.2021.789851/full; https://doaj.org/toc/1664-3224 |
| DOI: |
10.3389/fimmu.2021.789851 |
| Access URL: |
https://doaj.org/article/aa1b7cf172cf402dbbc624319124660f |
| Accession Number: |
edsdoj.1b7cf172cf402dbbc624319124660f |
| Database: |
Directory of Open Access Journals |
