Bibliographic Details
| Title: |
Study on the interaction between β-carotene and gut microflora using an in vitro fermentation model |
| Authors: |
Zhixian Li, Zhuqing Dai, Enjuan Shi, Peng Wan, Guijie Chen, Zhongyuan Zhang, Yayuan Xu, Ruichang Gao, Xiaoxiong Zeng, Dajing Li |
| Source: |
Food Science and Human Wellness, Vol 12, Iss 4, Pp 1369-1378 (2023) |
| Publisher Information: |
Tsinghua University Press, 2023. |
| Publication Year: |
2023 |
| Collection: |
LCC:Nutrition. Foods and food supply |
| Subject Terms: |
β-Carotene, Gut microflora, Retinol, Short-chain fatty acids, Nutrition. Foods and food supply, TX341-641 |
| More Details: |
β-Carotene, a typical non-oxygenated carotenoid, is the most efficient source of retinol (VA). The low bio-availability of β-carotene lead to large accumulation in colon; however, the relationship between β-carotene and gut microflora remains unclear. This study intends to explore the interaction between β-carotene and gut microflora using an in vitro fermentation model. After 24 h fermentation, the degradation rate of β-carotene was (64.28 ± 6.23)%, which was 1.46 times that of the group without gut microflora. Meanwhile, the production of VA was nearly 2 times that of the group without gut microflora, indicating that the gut microflora can metabolize β-carotene into VA. β-Carotene also influences the production of short-chain fatty acids (SCFAs), the production of total SCFAs in 0.5 mg/mL β-carotene (BCM) group was (44.00 ± 1.16) mmol/L, which was 2.26 times that of the blank control (BLK) group. Among them, the production of acetic acid in BCM group was (19.06 ± 0.82) mmol/L, which was 2.64 time that of the BLK group. Furthermore, β-carotene significantly affected the structure and composition of gut microflora, increasing the abundance of Roseburia, Parasutterella and Lachnospiraceae, and decreasing the abundance of Dialister, Collinsella and Enterobacter (P < 0.05). This study provides a new way to understand how β-carotene works in human body with gut microflora. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2213-4530 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S221345302200249X; https://doaj.org/toc/2213-4530 |
| DOI: |
10.1016/j.fshw.2022.10.030 |
| Access URL: |
https://doaj.org/article/1b5bc01dd5d343dab5366d3b238b41bd |
| Accession Number: |
edsdoj.1b5bc01dd5d343dab5366d3b238b41bd |
| Database: |
Directory of Open Access Journals |
