Bibliographic Details
| Title: |
Autonomous cortisol secretion in patients with primary aldosteronism: prevalence and implications on cardiometabolic profile and on surgical outcomes |
| Authors: |
Marta Araujo-Castro, Miguel Paja Fano, Begoña Pla Peris, Marga González Boillos, Eider Pascual-Corrales, Ana María García-Cano, Paola Parra Ramírez, Patricia Martín Rojas-Marcos, Jorge Gabriel Ruiz-Sanchez, Almudena Vicente, Emilia Gómez-Hoyos, Rui Ferreira, Iñigo García Sanz, Mónica Recasens, Rebeca Barahona San Millan, María José Picón César, Patricia Díaz Guardiola, Carolina Perdomo, Laura Manjón, Rogelio García-Centeno, Juan Carlos Percovich, Ángel Rebollo Román, Paola Gracia Gimeno, Cristina Robles Lázaro, Manuel Morales, María Calatayud, Simone Andree Furio Collao, Diego Meneses, Miguel Antonio Sampedro Nuñez, Verónica Escudero Quesada, Elena Mena Ribas, Alicia Sanmartín Sánchez, Cesar Gonzalvo Diaz, Cristina Lamas, Raquel Guerrero-Vázquez, María del Castillo Tous, Joaquín Serrano, Theodora Michalopoulou, Eva María Moya Mateo, Felicia Hanzu |
| Source: |
Endocrine Connections, Vol 12, Iss 9, Pp 1-10 (2023) |
| Publisher Information: |
Bioscientifica, 2023. |
| Publication Year: |
2023 |
| Collection: |
LCC:Diseases of the endocrine glands. Clinical endocrinology |
| Subject Terms: |
primary aldosteronism, autonomous cortisol secretion, dexamethasone suppression test, cardiometabolic profile, Diseases of the endocrine glands. Clinical endocrinology, RC648-665 |
| More Details: |
Purpose: The aim of this study was to evaluate the prevalence of autonomous cortisol secretion (ACS) in patients with primary aldosteronism (PA) and its implications on cardiometabolic and surgical outcomes. Methods: This is a retrospective multicenter study of PA patients who underwent 1 mg dexamethasone-suppression test (DST) during diagnostic workup in 21 Spanish tertiary hospitals. ACS was defined as a cortisol post-DST >1.8 μg/dL (confirmed ACS if >5 μg/dL and possible ACS if 1.8–5 μg/dL) in the absence of spe cific clinical features of hypercortisolism. The cardiometabolic profile was compared with a control group with ACS without PA (ACS group) matched for age and DST levels. Results: The prevalence of ACS in the global cohort of patients with PA (n = 176) was 29% (ACS–PA; n = 51). Ten patients had confirmed ACS and 41 possible ACS. The cardiometabolic profile of ACS–PA and PA-only patients was simil ar, except for older age and larger tumor size of the adrenal lesion in the ACS–PA group. When comparing the ACS–PA group (n = 51) and the ACS group (n = 78), the prevalence of hypertension (OR 7.7 (2.64–22.32)) and cardiovascular events (OR 5.0 (2.29–11.07)) was higher in ACS–PA patients than in ACS patients. The coexistence of ACS in patien ts with PA did not affect the surgical outcomes, the proportion of biochemical cure and clinical cure being similar between ACS–PA and PA-only groups. Conclusion: Co-secretion of cortisol and aldosterone affects almost one-thi rd of patients with PA. Its occurrence is more frequent in patients with larger tumors and advanced age. However, the cardiometabolic and surgical outcomes of patients with ACS–PA and PA-only are similar. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2049-3614 |
| Relation: |
https://ec.bioscientifica.com/view/journals/ec/12/9/EC-23-0043.xml; https://doaj.org/toc/2049-3614 |
| DOI: |
10.1530/EC-23-0043 |
| Access URL: |
https://doaj.org/article/a1abc4f735ed4d78b5e4afabe5763cd7 |
| Accession Number: |
edsdoj.1abc4f735ed4d78b5e4afabe5763cd7 |
| Database: |
Directory of Open Access Journals |
