Titanium-doped phosphate glasses containing zinc and strontium applied in bone regeneration

Bibliographic Details
Title:	Titanium-doped phosphate glasses containing zinc and strontium applied in bone regeneration
Authors:	Tianyi Tang, Rachel Wandless, Zalike Keskin-Erdogan, Nandin-Erdene Mandakhbayar, Jeong-Hui Park, Hae-Won Kim, Morgana Abramchuk, Felipe P. Daltoe, Jonathan C. Knowles
Source:	Journal of Materials Science: Materials in Medicine, Vol 35, Iss 1, Pp 1-10 (2024)
Publisher Information:	Springer, 2024.
Publication Year:	2024
Collection:	LCC:Materials of engineering and construction. Mechanics of materials LCC:Medical technology
Subject Terms:	Materials of engineering and construction. Mechanics of materials, TA401-492, Medical technology, R855-855.5
More Details:	Abstract Phosphate bioactive glass has been studied for its advanced biodegradability and active ion release capability. Our previous research found that phosphate glass containing (P2O5)–(Na2O)–(TiO2)–(CaO)–(SrO) or (ZnO) showed good biocompatibility with MG63 and hMSCs. This study further investigated the application of 5 mol% zinc oxide or 17.5 mol% strontium oxide in titanium-doped phosphate glass for bone tissue engineering. Ti-Ca-Na-Phosphate glasses, incorporating 5% zinc oxide or 17.5% strontium oxide, were made with melting quenching technology. The pre-osteoblast cell line MC3T3-E1 was cultured for indirect contact tests with graded diluted phosphate glass extractions and for direct contact tests by seeding cells on glass disks. The cell viability and cytotoxicity were analysed in vitro over 7 days. In vivo studies utilized the tibial defect model with or without glass implants. The micro-CT analysis was performed after surgery and then at 2, 6, and 12 weeks. Extractions from both zinc and strontium phosphate glasses showed no negative impact on MC3T3-E1 cell viability. Notably, non-diluted Zn-Ti-Ca-Na-phosphate glass extracts significantly increased cell viability by 116.8% (P
Document Type:	article
File Description:	electronic resource
Language:	English
ISSN:	1573-4838
Relation:	https://doaj.org/toc/1573-4838
DOI:	10.1007/s10856-024-06804-z
Access URL:	https://doaj.org/article/ee1aaa0f93ea41338f184b99a7c9cdfb
Accession Number:	edsdoj.1aaa0f93ea41338f184b99a7c9cdfb
Database:	Directory of Open Access Journals
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More Details
ISSN:	15734838
DOI:	10.1007/s10856-024-06804-z
Published in:	Journal of Materials Science: Materials in Medicine
Language:	English