Academic Journal
Diagnostic and predictive values of circulating tetrahydrobiopterin levels as a novel biomarker in patients with thoracic and abdominal aortic aneurysms
| Title: | Diagnostic and predictive values of circulating tetrahydrobiopterin levels as a novel biomarker in patients with thoracic and abdominal aortic aneurysms |
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| Authors: | Yixuan Zhang, Kin Lung Siu, Qiang Li, Kimberly Howard-Quijano, Jennifer Scovotti, Aman Mahajan, Hua Cai |
| Source: | Redox Biology, Vol 56, Iss , Pp 102444- (2022) |
| Publisher Information: | Elsevier, 2022. |
| Publication Year: | 2022 |
| Collection: | LCC:Medicine (General) LCC:Biology (General) |
| Subject Terms: | Aortic aneurysm, Thoracic aortic aneurysm (TAA), Abdominal aortic aneurysm (AAA), Tetrahydrobiopterin (H4B), eNOS uncoupling, Human patients, Medicine (General), R5-920, Biology (General), QH301-705.5 |
| More Details: | We have previously shown that circulating levels of tetrahydrobiopterin (H4B) function as a robust biomarker for aortic aneurysms in several independent animal models. In the present study, we examined diagnostic and predictive values of circulating H4B levels in human patients of thoracic aortic aneurysm (TAA) and abdominal aortic aneurysm (AAA) for the first time, while clinically applicable biomarkers for aortic aneurysms have never been previously available. Ninety-five patients scheduled for TAA repair surgeries and 53 control subjects were recruited at University of California Los Angeles (UCLA) Ronald Regan Medical Center, while 44 control subjects and 29 AAA patients were recruited through National Institute of Health (NIH) National Disease Research Interchange (NDRI) program. We had intriguing observations that circulating H4B levels were substantially lower in TAA and AAA patients, linearly correlated with aortic H4B levels (blood: R = 0.8071, p |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2213-2317 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2213231722002166; https://doaj.org/toc/2213-2317 |
| DOI: | 10.1016/j.redox.2022.102444 |
| Access URL: | https://doaj.org/article/dc1a9b0c07ef49d39d7a042e70431baf |
| Accession Number: | edsdoj.1a9b0c07ef49d39d7a042e70431baf |
| Database: | Directory of Open Access Journals |
| ISSN: | 22132317 |
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| DOI: | 10.1016/j.redox.2022.102444 |
| Published in: | Redox Biology |
| Language: | English |