Academic Journal
Evaluation of the Hemostatic Efficacy of Two Powdered Topical Absorbable Hemostats Using a Porcine Liver Abrasion Model of Mild to Moderate Bleeding
| Title: | Evaluation of the Hemostatic Efficacy of Two Powdered Topical Absorbable Hemostats Using a Porcine Liver Abrasion Model of Mild to Moderate Bleeding |
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| Authors: | Melinda H. MacDonald, Laura Tasse, Daidong Wang, Gary Zhang, Hector De Leon, Richard Kocharian |
| Source: | Journal of Investigative Surgery, Vol 34, Iss 11, Pp 1198-1206 (2021) |
| Publisher Information: | Taylor & Francis Group, 2021. |
| Publication Year: | 2021 |
| Collection: | LCC:Surgery |
| Subject Terms: | surgical hemostasis, oxidized cellulose, thrombin, adjunctive hemostat, topical absorbable hemostat, hemostatic powder, experimental animal model, liver abrasion model, surgical blood loss, collagen, Surgery, RD1-811 |
| More Details: | Introduction Topical hemostatic agents, used alone or in combination, have become common adjuncts to manage tissue and organ bleeding resulting from trauma and surgical procedures. Oxidized regenerated cellulose (ORC) is one of the most commonly used adjunctive hemostatic agents. The aim of the present study was to compare the hemostatic efficacy of a novel ORC-based product, SURGICEL® Powder Absorbable Hemostat (Surgicel-P) to that of HEMOBLAST™ Bellows (Hemoblast-B), a collagen-based combination powder. Methods Using an established porcine liver abrasion model, we randomly tested Surgicel-P and Hemoblast-B in 60 experimental lesion sites (30 per product tested). Primary endpoints included hemostatic efficacy measured by absolute time to hemostasis (TTH) within 5 minutes. We also examined number of applications required to achieve hemostasis, and sustained hemostasis following saline irrigation of test sites that achieved hemostasis. Results Surgicel-P demonstrated significantly higher hemostatic efficacy and lower TTH (p |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 0894-1939 1521-0553 08941939 |
| Relation: | https://doaj.org/toc/0894-1939; https://doaj.org/toc/1521-0553 |
| DOI: | 10.1080/08941939.2020.1792007 |
| Access URL: | https://doaj.org/article/1a699b473db24a69b8dda30707a60347 |
| Accession Number: | edsdoj.1a699b473db24a69b8dda30707a60347 |
| Database: | Directory of Open Access Journals |
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| ISSN: | 08941939 15210553 |
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| DOI: | 10.1080/08941939.2020.1792007 |
| Published in: | Journal of Investigative Surgery |
| Language: | English |