Bibliographic Details
| Title: |
Genetic tools for the development of recombinant lactic acid bacteria |
| Authors: |
Jiapeng Wu, Yongping Xin, Jian Kong, Tingting Guo |
| Source: |
Microbial Cell Factories, Vol 20, Iss 1, Pp 1-10 (2021) |
| Publisher Information: |
BMC, 2021. |
| Publication Year: |
2021 |
| Collection: |
LCC:Microbiology |
| Subject Terms: |
Lactic acid bacteria, Food-grade microorganisms, Genome-editing tools, Probiotic characteristics, Therapeutic functionalities, Microbiology, QR1-502 |
| More Details: |
Abstract Lactic acid bacteria (LAB) are a phylogenetically diverse group with the ability to convert soluble carbohydrates into lactic acid. Many LAB have a long history of safe use in fermented foods and are recognized as food-grade microorganisms. LAB are also natural inhabitants of the human intestinal tract and have beneficial effects on health. Considering these properties, LAB have potential applications as biotherapeutic vehicles to delivery cytokines, antigens and other medicinal molecules. In this review, we summarize the development of, and advances in, genome manipulation techniques for engineering LAB and the expected future development of such genetic tools. These methods are crucial for us to maximize the value of LAB. We also discuss applications of the genome-editing tools in enhancing probiotic characteristics and therapeutic functionalities of LAB. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1475-2859 |
| Relation: |
https://doaj.org/toc/1475-2859 |
| DOI: |
10.1186/s12934-021-01607-1 |
| Access URL: |
https://doaj.org/article/1a432a8d79f047f888062913aa2e9c27 |
| Accession Number: |
edsdoj.1a432a8d79f047f888062913aa2e9c27 |
| Database: |
Directory of Open Access Journals |
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