Bibliographic Details
| Title: |
Factors contributing to the diagnosis and onset prediction of perennial allergic rhinitis in high-risk children: A sub-analysis of the CHIBA study |
| Authors: |
Syuji Yonekura, Yoshitaka Okamoto, Fumiya Yamaide, Taiji Nakano, Kiyomi Hirano, Urara Funakoshi, Sawako Hamasaki, Tomohisa Iinuma, Toyoyuki Hanazawa, Naoki Shimojo |
| Source: |
Allergology International, Vol 73, Iss 3, Pp 436-444 (2024) |
| Publisher Information: |
Elsevier, 2024. |
| Publication Year: |
2024 |
| Collection: |
LCC:Immunologic diseases. Allergy |
| Subject Terms: |
Allergies, House dust mite, Nasal eosinophils, Perennial allergic rhinitis, Sensitization, Immunologic diseases. Allergy, RC581-607 |
| More Details: |
Background: This study aimed to clarify the diagnostic and predictive factors for perennial allergic rhinitis (PAR) onset in children by analyzing the results of the Chiba High-risk Birth Cohort for Allergy study, which examined newborns with a family history of allergies. Methods: Overall, 306 pregnant women were recruited. Their newborns were examined by otolaryngologists and pediatric allergists at 1, 2, and 5 years of age. Participants with clinical and laboratory data available at all consultation points were considered eligible. Results: Among 187 eligible participants, the prevalence rates of PAR were 2.1%, 4.3%, and 24.1% at 1, 2, and 5 years of age, respectively. AR-specific nasal local findings and eosinophils in nasal smear were observed in a substantial number of patients with PAR at 1 and 2 years of age. Factors present up to 2 years of age that were associated with PAR onset at 5 years of age, in descending order, were as follows: sensitization to house dust mites (HDM), nasal eosinophilia, and sensitization to cat dander. In 44 cases with HDM sensitization, nasal eosinophilia up to 2 years of age achieved a sensitivity of 76.0% and a specificity of 73.7% for predicting PAR onset at 5 years. Conclusions: Rhinitis findings and nasal eosinophilia are useful auxiliary diagnostic items for pediatric PAR. Sensitization to HDM and nasal eosinophilia were the most influential factors associated with future PAR onset. A combination of these factors may facilitate the prediction of PAR onset. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1323-8930 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S1323893024000133; https://doaj.org/toc/1323-8930 |
| DOI: |
10.1016/j.alit.2024.01.012 |
| Access URL: |
https://doaj.org/article/1a1c9649914f4cc082d13efac2542ddc |
| Accession Number: |
edsdoj.1a1c9649914f4cc082d13efac2542ddc |
| Database: |
Directory of Open Access Journals |
