Academic Journal
Longitudinal profiles of the fecal metabolome during the first 2 years of life
| Title: | Longitudinal profiles of the fecal metabolome during the first 2 years of life |
|---|---|
| Authors: | Elizabeth A. Holzhausen, Natalie Shen, Bridget Chalifour, ViLinh Tran, Zhenjiang Li, Jeremy A. Sarnat, Howard H. Chang, Dean P. Jones, Michael I. Goran, Donghai Liang, Tanya L. Alderete |
| Source: | Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023) |
| Publisher Information: | Nature Portfolio, 2023. |
| Publication Year: | 2023 |
| Collection: | LCC:Medicine LCC:Science |
| Subject Terms: | Medicine, Science |
| More Details: | Abstract During the first 2 years of life, the infant gut microbiome is rapidly developing, and gut bacteria may impact host health through the production of metabolites that can have systemic effects. Thus, the fecal metabolome represents a functional readout of gut bacteria. Despite the important role that fecal metabolites may play in infant health, the development of the infant fecal metabolome has not yet been thoroughly characterized using frequent, repeated sampling during the first 2 years of life. Here, we described the development of the fecal metabolome in a cohort of 101 Latino infants with data collected at 1-, 6-, 12-, 18-, and 24-months of age. We showed that the fecal metabolome is highly conserved across time and highly personalized, with metabolic profiles being largely driven by intra-individual variability. Finally, we also identified several novel metabolites and metabolic pathways that changed significantly with infant age, such as valerobetaine and amino acid metabolism, among others. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2045-2322 |
| Relation: | https://doaj.org/toc/2045-2322 |
| DOI: | 10.1038/s41598-023-28862-z |
| Access URL: | https://doaj.org/article/c1a147d4df544f02b94276482c85bd03 |
| Accession Number: | edsdoj.1a147d4df544f02b94276482c85bd03 |
| Database: | Directory of Open Access Journals |
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| ISSN: | 20452322 |
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| DOI: | 10.1038/s41598-023-28862-z |
| Published in: | Scientific Reports |
| Language: | English |