Improving STING agonist-based cancer therapy by inhibiting the autophagy-related protein VPS34

Bibliographic Details
Title:	Improving STING agonist-based cancer therapy by inhibiting the autophagy-related protein VPS34
Authors:	Elisabetta Bartolini, Kris Van Moer, Bassam Janji
Source:	OncoImmunology, Vol 13, Iss 1 (2024)
Publisher Information:	Taylor & Francis Group, 2024.
Publication Year:	2024
Collection:	LCC:Immunologic diseases. Allergy LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Subject Terms:	Autophagy, CCL5, CD8 T cells, CXCL10, immunotherapy, melanoma, Immunologic diseases. Allergy, RC581-607, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
More Details:	We have recently demonstrated that inhibiting VPS34 enhances T-cell-recruiting chemokines through the activation of the cGAS/STING pathway using the STING agonist ADU-S100. Combining VPS34 inhibitors with ADU-S100 increased cytokine release and improved tumor control in mouse models, suggesting a potential synergy between VPS34 inhibition and therapies based on STING agonists.
Document Type:	article
File Description:	electronic resource
Language:	English
ISSN:	2162402X 2162-402X
Relation:	https://doaj.org/toc/2162-402X
DOI:	10.1080/2162402X.2024.2364958
Access URL:	https://doaj.org/article/1a089f9a99864f57b16e12dca7799881
Accession Number:	edsdoj.1a089f9a99864f57b16e12dca7799881
Database:	Directory of Open Access Journals