Outcome of COVID-19-positive children with heart disease and grown-ups with congenital heart disease: A multicentric study from India
| Title: | Outcome of COVID-19-positive children with heart disease and grown-ups with congenital heart disease: A multicentric study from India |
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| Authors: | Sakshi Sachdeva, Sivasubramanian Ramakrishnan, Mrigank Choubey, Nageswara Rao Koneti, Kalaivani Mani, Shweta Bakhru, Saurabh Kumar Gupta, Debasree Gangopadhyay, Soumya Kasturi, Jayashree Mishra, Hemant Kumar Nayak, Kothandam Sivakumar, Prashant Bobhate, Neeraj Awasthy, Debasis Das, Manisha Chakrabarti, Chinnaswamy Sivaprakasam Muthukumaran, Rajan Saileela, Bhargavi Dhulipudi, Shiv Kumar Chaudhary, Mahimarangaiah Jayranganath, Anita Saxena, Krishna Subramony Iyer, Raman Krishna Kumar, Shyam S Kothari, Snehal Kulkarni, Suresh G Rao, For the PCSI-COVID-19 study group |
| Source: | Annals of Pediatric Cardiology, Vol 14, Iss 3, Pp 269-277 (2021) |
| Publisher Information: | Wolters Kluwer Medknow Publications, 2021. |
| Publication Year: | 2021 |
| Collection: | LCC:Medicine LCC:Pediatrics LCC:Diseases of the circulatory (Cardiovascular) system |
| Subject Terms: | congenital heart disease, grown-ups with congenital heart disease, low- and middle-income countries and sars-cov-2 infection, outcome, surgery, Medicine, Pediatrics, RJ1-570, Diseases of the circulatory (Cardiovascular) system, RC666-701 |
| More Details: | Background : Outcome data of children with heart disease who acquired COVID-19 infection are limited. Aims : We sought to analyze outcome data and identify risk factors associated with mortality in children with heart disease and grown-ups with congenital heart disease (GUCH) who had a laboratory-confirmed COVID-19 infection. Settings and Design : This is a retrospective, multicentric, observational study. Materials and Methods : The study included children with heart disease and GUCH population, who presented with either symptomatic or asymptomatic COVID-19 infection to any of the participating centers. COVID-19-negative patients admitted to these centers constituted the control group. Results : From 24 pediatric cardiac centers across India, we included 94 patients with a median age of 12.5 (interquartile range 3–96) months and 49 (52.1%) patients were males. Majority (83 patients, 88.3%) were children. One-third of the patients (n = 31, 33.0%) had acyanotic congenital heart disease, and 41.5% (n = 39) were cyanotic, with > 80% of the patients being unoperated. Only 30 (31.9%) patients were symptomatic for COVID-19 infection, while the rest were incidentally detected positive on screening. A total of 13 patients died (case fatality rate: 13.8%). The in-hospital mortality rate among hospitalized patients was significantly higher among COVID-19-positive cases (13 of 48; 27.1%) as compared to COVID-negative admissions (9.2%) during the study period (P < 0.001). On multivariate analysis, the independent predictors of mortality among COVID-19-positive cases were severity of illness at admission (odds ratio [OR]: 535.7, 95% confidence interval [CI]: 6.9–41,605, P = 0.005) and lower socioeconomic class (OR: 29.5, 95% CI: 1.1–814.7, P = 0.046). Conclusions : Children with heart disease are at a higher risk of death when they acquire COVID-19 infection. Systematic preventive measures and management strategies are needed for improving the outcomes. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 0974-2069 |
| Relation: | http://www.annalspc.com/article.asp?issn=0974-2069;year=2021;volume=14;issue=3;spage=269;epage=277;aulast=Sachdeva; https://doaj.org/toc/0974-2069 |
| DOI: | 10.4103/apc.apc_134_21 |
| Access URL: | https://doaj.org/article/18dcb228e9b7483ca97dd6517224afb7 |
| Accession Number: | edsdoj.18dcb228e9b7483ca97dd6517224afb7 |
| Database: | Directory of Open Access Journals |
| ISSN: | 09742069 |
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| DOI: | 10.4103/apc.apc_134_21 |
| Published in: | Annals of Pediatric Cardiology |
| Language: | English |