Bibliographic Details
| Title: |
Identification of a Novel Synthetic Cathinone CMMP |
| Authors: |
HE Si-yang, DENG Qian-ya, ZHENG Shui-qing, NI Chun-fang, SUN Wen-juan, CAO Fang-qi, LIANG Chen, GONG Fei-jun |
| Source: |
Fayixue Zazhi, Vol 40, Iss 6, Pp 550-556 (2024) |
| Publisher Information: |
Editorial Office of Journal of Forensic Medicine, 2024. |
| Publication Year: |
2024 |
| Collection: |
LCC:Medicine |
| Subject Terms: |
forensic medicine, toxicological analysis, new psychoactive substance （nps）, synthetic cathinones, 2-methyl-1-[4-（methylthio）phenyl]-2-morpholinopropan-1-one （mtmp）, 1-（4-chlorophenyl）-2-methyl-2-morpholinopropan-1-one （cmmp）, high resolution mass spectrometry （hrms）, n-morpholine substituted, Medicine |
| More Details: |
ObjectiveTo establish a method to identify an unknown substance based on the combined use of gas chromatography-quadrupole time-of-flight mass spectrometry （GC-QTOF-MS）, ultra-high performance liquid chromatography-quadrupole/electrostatic field orbitrap high resolution mass spectrometry （UPLC-Q/Orbitrap HRMS）and nuclear magnetic resonance （NMR） techniques.MethodsThe unknown substance was dissolved in methanol and was detected by GC-QTOF-MS and UPLC-Q/Orbitrap HRMS, and was dissolved in methanol-d4 to be detected by NMR.ResultsThe main characteristics ion peaks of components with retention time of 9.67 min in GC-QTOF-MS measured were 84.080 8, 110.999 7, 128.107 0 （base peak）, 138.994 7, etc. The protonated molecular ion peak m/z in UPLC-Q/Orbitrap HRMS was 268.109 3. It was inferred that the unknown substance was an analog of the synthetic cathinone substance 2-methyl-1-[4-（methylthio）phenyl]-2-morpholinopropan-1-one （MTMP） by comparing the mass spectrum information and molecular structure of MTMP. NMR analysis confirmed it as a novel N-morpholine substituted synthetic cathinone substance 1-（4-chlorophenyl）-2-methyl-2-morpholinopropan-1-one （CMMP）.ConclusionThe method established in this study can be used for structural confirmation of CMMP. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
Chinese |
| ISSN: |
1004-5619 |
| Relation: |
http://www.fyxzz.cn/CN/10.12116/j.issn.1004-5619.2024.340103; https://doaj.org/toc/1004-5619 |
| DOI: |
10.12116/j.issn.1004-5619.2024.340103 |
| Access URL: |
https://doaj.org/article/a188e230b4f64e04841a43d69f1a9aa0 |
| Accession Number: |
edsdoj.188e230b4f64e04841a43d69f1a9aa0 |
| Database: |
Directory of Open Access Journals |
