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Biophysical insights into the binding capability of Cu(II) schiff base complex with BSA protein and cytotoxicity studies against SiHa

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Title: Biophysical insights into the binding capability of Cu(II) schiff base complex with BSA protein and cytotoxicity studies against SiHa
Authors: Minakshi Maity, Ushasi Pramanik, Venkatesha R. Hathwar, Paula Brandao, Saptarshi Mukherjee, Swapan Maity, Ribhu Maity, Tithi Maity, Bidhan Chandra Samanta
Source: Heliyon, Vol 8, Iss 11, Pp e11345- (2022)
Publisher Information: Elsevier, 2022.
Publication Year: 2022
Collection: LCC:Science (General)
LCC:Social sciences (General)
Subject Terms: BSA quencher, Cu(II) complex, Cytotoxicity, Schiff base, SiHa cancer cell, Science (General), Q1-390, Social sciences (General), H1-99
More Details: Herein, we have explored the effects of chlorinated mononuclear Cu(II) complex upon binding with BSA protein (bovine serum albumin) and its in vitro anti-proliferative potentiality against SiHa cell. The complex was synthesized involving a Schiff base ligand having N,N,O donor centers and characterized by several spectroscopic studies. Structure, DFT studies and Hirshfeld surface (HS) analyses were identified using crystallographic computational studies. The binding interaction with BSA depicts the efficacy of the complex towards promising binding of it with BSA. Further, the complex shows a moderate cytotoxicity against SiHa cancer cell signifying its potentiality as an anti-proliferative agent for human cervix uteri carcinoma.
Document Type: article
File Description: electronic resource
Language: English
ISSN: 2405-8440
Relation: http://www.sciencedirect.com/science/article/pii/S2405844022026330; https://doaj.org/toc/2405-8440
DOI: 10.1016/j.heliyon.2022.e11345
Access URL: https://doaj.org/article/186e9f5e1ac4451b961f7361916f0043
Accession Number: edsdoj.186e9f5e1ac4451b961f7361916f0043
Database: Directory of Open Access Journals
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  Data: Biophysical insights into the binding capability of Cu(II) schiff base complex with BSA protein and cytotoxicity studies against SiHa
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  Data: <searchLink fieldCode="AR" term="%22Minakshi+Maity%22">Minakshi Maity</searchLink><br /><searchLink fieldCode="AR" term="%22Ushasi+Pramanik%22">Ushasi Pramanik</searchLink><br /><searchLink fieldCode="AR" term="%22Venkatesha+R%2E+Hathwar%22">Venkatesha R. Hathwar</searchLink><br /><searchLink fieldCode="AR" term="%22Paula+Brandao%22">Paula Brandao</searchLink><br /><searchLink fieldCode="AR" term="%22Saptarshi+Mukherjee%22">Saptarshi Mukherjee</searchLink><br /><searchLink fieldCode="AR" term="%22Swapan+Maity%22">Swapan Maity</searchLink><br /><searchLink fieldCode="AR" term="%22Ribhu+Maity%22">Ribhu Maity</searchLink><br /><searchLink fieldCode="AR" term="%22Tithi+Maity%22">Tithi Maity</searchLink><br /><searchLink fieldCode="AR" term="%22Bidhan+Chandra+Samanta%22">Bidhan Chandra Samanta</searchLink>
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  Data: Heliyon, Vol 8, Iss 11, Pp e11345- (2022)
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  Data: Elsevier, 2022.
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  Data: <searchLink fieldCode="DE" term="%22BSA+quencher%22">BSA quencher</searchLink><br /><searchLink fieldCode="DE" term="%22Cu%28II%29+complex%22">Cu(II) complex</searchLink><br /><searchLink fieldCode="DE" term="%22Cytotoxicity%22">Cytotoxicity</searchLink><br /><searchLink fieldCode="DE" term="%22Schiff+base%22">Schiff base</searchLink><br /><searchLink fieldCode="DE" term="%22SiHa+cancer+cell%22">SiHa cancer cell</searchLink><br /><searchLink fieldCode="DE" term="%22Science+%28General%29%22">Science (General)</searchLink><br /><searchLink fieldCode="DE" term="%22Q1-390%22">Q1-390</searchLink><br /><searchLink fieldCode="DE" term="%22Social+sciences+%28General%29%22">Social sciences (General)</searchLink><br /><searchLink fieldCode="DE" term="%22H1-99%22">H1-99</searchLink>
– Name: Abstract
  Label: Description
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  Data: Herein, we have explored the effects of chlorinated mononuclear Cu(II) complex upon binding with BSA protein (bovine serum albumin) and its in vitro anti-proliferative potentiality against SiHa cell. The complex was synthesized involving a Schiff base ligand having N,N,O donor centers and characterized by several spectroscopic studies. Structure, DFT studies and Hirshfeld surface (HS) analyses were identified using crystallographic computational studies. The binding interaction with BSA depicts the efficacy of the complex towards promising binding of it with BSA. Further, the complex shows a moderate cytotoxicity against SiHa cancer cell signifying its potentiality as an anti-proliferative agent for human cervix uteri carcinoma.
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      – Text: English
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      – SubjectFull: BSA quencher
        Type: general
      – SubjectFull: Cu(II) complex
        Type: general
      – SubjectFull: Cytotoxicity
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      – SubjectFull: Schiff base
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      – SubjectFull: SiHa cancer cell
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