Academic Journal
Biophysical insights into the binding capability of Cu(II) schiff base complex with BSA protein and cytotoxicity studies against SiHa
| Title: | Biophysical insights into the binding capability of Cu(II) schiff base complex with BSA protein and cytotoxicity studies against SiHa |
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| Authors: | Minakshi Maity, Ushasi Pramanik, Venkatesha R. Hathwar, Paula Brandao, Saptarshi Mukherjee, Swapan Maity, Ribhu Maity, Tithi Maity, Bidhan Chandra Samanta |
| Source: | Heliyon, Vol 8, Iss 11, Pp e11345- (2022) |
| Publisher Information: | Elsevier, 2022. |
| Publication Year: | 2022 |
| Collection: | LCC:Science (General) LCC:Social sciences (General) |
| Subject Terms: | BSA quencher, Cu(II) complex, Cytotoxicity, Schiff base, SiHa cancer cell, Science (General), Q1-390, Social sciences (General), H1-99 |
| More Details: | Herein, we have explored the effects of chlorinated mononuclear Cu(II) complex upon binding with BSA protein (bovine serum albumin) and its in vitro anti-proliferative potentiality against SiHa cell. The complex was synthesized involving a Schiff base ligand having N,N,O donor centers and characterized by several spectroscopic studies. Structure, DFT studies and Hirshfeld surface (HS) analyses were identified using crystallographic computational studies. The binding interaction with BSA depicts the efficacy of the complex towards promising binding of it with BSA. Further, the complex shows a moderate cytotoxicity against SiHa cancer cell signifying its potentiality as an anti-proliferative agent for human cervix uteri carcinoma. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2405-8440 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2405844022026330; https://doaj.org/toc/2405-8440 |
| DOI: | 10.1016/j.heliyon.2022.e11345 |
| Access URL: | https://doaj.org/article/186e9f5e1ac4451b961f7361916f0043 |
| Accession Number: | edsdoj.186e9f5e1ac4451b961f7361916f0043 |
| Database: | Directory of Open Access Journals |
| ISSN: | 24058440 |
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| DOI: | 10.1016/j.heliyon.2022.e11345 |
| Published in: | Heliyon |
| Language: | English |