Academic Journal
Optimizing the aldosterone-to-renin ratio cut-off for screening primary aldosteronism based on cardiovascular risk: a collaborative study
| Title: | Optimizing the aldosterone-to-renin ratio cut-off for screening primary aldosteronism based on cardiovascular risk: a collaborative study |
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| Authors: | Chunxue He, Ruolin Li, Jun Yang, Hang Shen, Yue Wang, Xiangjun Chen, Wenjin Luo, Qinglian Zeng, Linqiang Ma, Ying Song, Qingfeng Cheng, Zhihong Wang, Fei-Fei Wu, Qifu Li, Shumin Yang, Jinbo Hu |
| Source: | Clinical and Experimental Hypertension, Vol 46, Iss 1 (2024) |
| Publisher Information: | Taylor & Francis Group, 2024. |
| Publication Year: | 2024 |
| Collection: | LCC:Diseases of the circulatory (Cardiovascular) system |
| Subject Terms: | Aldosterone-to-renin ratio, cardiovascular risk, cutoff, primary aldsoteronism, screening, Diseases of the circulatory (Cardiovascular) system, RC666-701 |
| More Details: | Objectives Aldosterone-to-renin ratio (ARR) based screening is the first step in the diagnosis of primary aldosteronism (PA). However, the guideline-recommended ARR cutoff covers a wide range, from the equivalent of 1.3 to 4.9 ng·dl−1/mIU∙l−1. We aimed to optimize the ARR cutoff for PA screening based on the risk of cardiovascular diseases (CVD).Methods Longitudinally, we included hypertensive participants from the Framingham Offspring Study (FOS) who attended the sixth examination cycle and followed up until 2014. At baseline (1995–1998), we used circulating concentrations of aldosterone and renin to calculate ARR (unit: ng·dl−1/mIU∙l−1) among 1,433 subjects who were free of CVD. We used spline regression to calculate the ARR threshold based on the incident CVD. We used cross-sectional data from the Chongqing Primary Aldosteronism Study (CONPASS) to explore whether the ARR cutoff selected from FOS is applicable to PA screening.Results In FOS, CVD risk increased with an increasing ARR until a peak of ARR 1.0, followed by a plateau in CVD risk (hazard ratio 1.49, 95%CI 1.19–1.86). In CONPASS, when compared to essential hypertension with ARR |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 10641963 1525-6006 1064-1963 |
| Relation: | https://doaj.org/toc/1064-1963; https://doaj.org/toc/1525-6006 |
| DOI: | 10.1080/10641963.2023.2301571 |
| Access URL: | https://doaj.org/article/180268ee7dd145ed9c578a254007ea85 |
| Accession Number: | edsdoj.180268ee7dd145ed9c578a254007ea85 |
| Database: | Directory of Open Access Journals |
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| ISSN: | 10641963 15256006 |
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| DOI: | 10.1080/10641963.2023.2301571 |
| Published in: | Clinical and Experimental Hypertension |
| Language: | English |